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Citations

Abgent's innovative products and custom services for the study of proteomic modifications rank us as a cited supplier in Nature's 2003 Antibody Technology and 2004 Drug Discovery Features, and in The Scientist's 2003 Cell Signaling Feature. Representative product citations appear in the peer reviewed publications below:

Sumoylation & Ubiquitination
Phosphorylation - Kinases & Phosphatases
Acetylation & Methylation
Other Protein Modifications
Cellular Function & Disease
Tag Specific
Custom Services - Peptide Synthesis
Custom Services - Antibody Production
Custom Services - Protein Expression
Tools

Sumoylation & Ubiquitination

Product	Citation
AP1152b SUSP1 Antibody (N-term) Updated info	Choi, S.J. et al. Negative Modulation of RXR alpha Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1. J. Biol Chem. 2006. 281(41): 30669 - 30677.	Abstract Full Article
AP1222a SUMO1 Antibody (C-term)	Cindy Degerny et al. SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity. J. Biol. Chem., Jul 2005; 280: 24330 - 24338.	Abstract
AP1224a SUMO2/3 C-term Antibody	Cindy Degerny et al. SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity. J. Biol. Chem., Jul 2005; 280: 24330 - 24338.	Abstract
AP1229a Ubiquitin Antibody (C-term)	Sonja C. Vernes, et al. Functional genetic analysis of mutations implicated in a human speech and language disorder Hum. Mol. Genet., Sep 2006; 10.1093/hmg/ddl392.	Abstract
AP1239a SENP6 Antibody (C-term)	Marius C. Jones et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. PNAS. Oct 2006, 10.1073/pnas.0603002103
AP1244a PIAS3 Antibody (C-term)	Wetzler, M., et al. Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation. Clin. Cancer Res. 2006. 12: 6817 - 6825.	Abstract
AP1244a PIAS3 Antibody (C-term)	Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation. Meir Wetzler et al. Clin. Cancer Res. Nov 2006; 12: 6817 - 6825.
AP1248a PIASx1 Antibody (N-term)	Marius C. Jones et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. PNAS. Oct 2006, 10.1073/pnas.0603002103
AP1249a PIASy1 Antibody (N-term)	Amador Albor et al. The Interaction of Piasy with Trim32, an E3-Ubiquitin Ligase Mutated in Limb-girdle Muscular Dystrophy Type 2H, Promotes Piasy Degradation and Regulates UVB-induced Keratinocyte Apoptosis through NF B. J. Biol. Chem., Sep 2006; 281: 25850 - 25866.	Abstract
AP2104a SMURF1 Antibody (N-term)	Kaneki, H., et al. Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts. J. Biol. Chem. 2006. 281: 4326 - 4333.	Abstract Full Article
AP2104a SMURF1 Antibody (N-term)	Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts. Hiroyuki Kaneki et al. J. Biol. Chem. Feb 2006; 281: 4326 - 4333.
AP2118a UBE2L6 Antibody (N-term)	Joyce Jing Yi Wong et al. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. PNAS, Jul 2006; 103: 10735 - 10740.	Abstract
AP2131 USP2 Antibody (N-term)	Carmen Priolo et al. The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis. Cancer Res., Sep 2006; 66: 8625 - 8632.	Abstract
AP2131 USP2 Antibody (C-term L523 )	Carmen Priolo et al. The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis. Cancer Res., Sep 2006; 66: 8625 - 8632.	Abstract
AP2184a HRD1 Antibody (C-term)	Takahiro Yamada et al. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic ß-cells. Hum. Mol. Genet., May 2006; 15: 1600 - 1609.	Abstract
AP2514b CBX4 Antibody (C-term)	Marius C. Jones et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. PNAS. Oct 2006, 10.1073/pnas.0603002103
AP7237c SPHK1 Antibody (Center)	Sun, J., et al. FHL2/SLIM3 Decreases Cardiomyocyte Survival by Inhibitory Interaction With Sphingosine Kinase-1. Circ. Res. 2006. 99: 468 - 476.	Abstract Full Article
AP7237c SPHK1 Antibody (Center)	FHL2/SLIM3 Decreases Cardiomyocyte Survival by Inhibitory Interaction With Sphingosine Kinase-1. Jianxin Sun at al. Circ. Res. Sep 2006; 99: 468 - 476.
AP8004a HGK Antibody (C-term)	Bouzakri, K. et al. MAP4K4 gene silencing in human skeletal muscle prevents TNF-α-induced insulin resistance. J. Biol. Chem. Jan 2007; 10.1074/jbc.M608602200.	Abstract

Phosphorylation - Kinases & Phosphatases

Product	Citation
AM8109a IKK beta Antibody	Andreas Panopoulos, et al. Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor -Induced but Not Interleukin-1-induced IB Kinase Complex/Nuclear Factor-B Activation. J. Biol. Chem., Jan 2005; 280: 2912 - 2923.	Abstract
AM8110a IKK gamma Antibody	Andreas Panopoulos, et al. Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor -Induced but Not Interleukin-1-induced IB Kinase Complex/Nuclear Factor-B Activation. J. Biol. Chem., Jan 2005; 280: 2912 - 2923.	Abstract
AP3104a Phospho-FGFR-pY653/654 Antibody	Francesco Facchiano et al. Glycated Fibroblast Growth Factor-2 Is Quickly Produced in Vitro upon Low-Millimolar Glucose Treatment and Detected in Vivo in Diabetic Mice. Mol. Endocrinol. 2006; 20: 2806-2818.
AP7000b Aurora-C Antibody (C-term)	Priya Kapoor et al. EBP2 Plays a Key Role in Epstein-Barr Virus Mitotic Segregation and Is Regulated by Aurora Family Kinases. Mol. Cell. Biol., Jun 2005; 25: 4934 - 4945.	Abstract
AP7011a MSK2 Antibody (C-term R321)	Elliot R. Lee et al. Dynamic Changes in Histone H3 Phosphoacetylation during Early Embryonic Stem Cell Differentiation Are Directly Mediated by Mitogen- and Stress-activated Protein Kinase 1 via Activation of MAPK Pathways. J. Biol. Chem., Jul 2006; 281: 21162 - 21172.	Abstract
AP7011a MSK2 Antibody (C-term R321)	Katherine Dunn et al. The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. Biochem Cell Biol., Feb2005; 83(1):1-14.	Abstract
AP7016b PKC beta2 Antibody (C-term)	Maines, M.D., et al. Human biliverdin reductase: A previously unknown activator of protein kinase C β II. J. Biol. Chem. Jan 2007; 10.1074/jbc.M513427200.	Abstract
AP7033a DAPK2 Antibody (N-term)	V.G. Karur et al. Lyn kinase promotes erythroblast expansion and late-stage development. Blood, Sep 2006; 108: 1524 - 1532.	Abstract
AP7039b PDK2 Antibody (C-term )	Zhang, Y., et al. Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression. Yi Zhang et al. J. Biol. Chem. Dec 2006; 281: 39897 - 39906.	Abstract Full Article
AP7039b PDK2 Antibody (C-term )	Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression. Yi Zhang et al. J. Biol. Chem. Dec 2006; 281: 39897 - 39906.
AP7039b PDK2 Antibody (C-term )	Eric N. Churchill et al. Reperfusion-Induced Translocation of PKC to Cardiac Mitochondria Prevents Pyruvate Dehydrogenase Reactivation. Circ. Res., Jul 2005; 97: 78 - 85.	Abstract
AP7041b PDK4 Antibody (C-term)	Long, Y.C., et al. Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression. J. Biol. Chem. 2006. 282(3):1607 - 1614	Abstract
AP7041b PDK4 Antibody (C-term)	Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression. Yun Chau Long et al. J. Biol. Chem. Nov 2006; 10.1074/jbc.M609208200.
AP7094b PGK1 Antibody (Center)	Andrew B. West et al. From The Cover: Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. PNAS, Nov 2005; 102: 16842 - 16847.	Abstract
AP7221b DRAK2 Antibody (C-term )	Jianning Mao et al. Transgenic DRAK2 overexpression in mice leads to increased T-cell apoptosis and compromised memory T-cell development. J. Biol. Chem., Mar 2006; 10.1074/jbc.M600497200.	Abstract
AP7538b DYRKB Antibody (C-term)	Fumi Takahashi-Yanaga et al. Involvement of GSK-3 and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells J. Biol. Chem. Oct 2006, 10.1074/jbc.M605205200
AP7540b HIPK3 Antibody (C-term)	Lan, H.C., et al. Cyclic AMP stimulates SF-1 dependent CYP11A1 expression through HIPK3 mediated JNK and c-Jun phosphorylation. Mol. Cell. Biol. 27(6): 2027 - 2036.	Abstract
AP7546b P38 Antibody (C-term )	Edward O. McFalls et al. Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardium. Am J Physiol Heart Circ Physiol, Sep 2004; 287: 1328 - 1334.	Abstract
AP7636a FGFR1 Antibody (N-term)	Abha Sahni and Charles W. Francis. Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires v3. Blood, Dec 2004; 104: 3635 - 3641.	Abstract
AP7653a INSR Antibody (N-term)	Miyako Takaki et al. In Vitro Formation of Enteric Neural Network Structure in a Gut-Like Organ Differentiated from Mouse Embryonic Stem Cells. Stem Cells, Jun 2006; 24: 1414 - 1422.	Abstract
AP7664a MUSK Antibody (N-term)	Frederic Chevessier, et al. MUSK, a new target for mutations causing congenital myasthenic syndrome. Hum. Mol. Genet., Dec 2004; 13: 3229 - 3240.	Abstract
AP7677b RYK Antibody (C-term)	Thomas R. Keeble et al. The Wnt Receptor Ryk Is Required for Wnt5a-Mediated Axon Guidance on the Contralateral Side of the Corpus Callosum. J. Neurosci., May 2006; 26: 5840 - 5848.	Abstract
AP7806c ACVR1 Antibody (Center R147)	Frank Weber et al. A Limited Set of Human MicroRNA Is Deregulated in Follicular Thyroid Carcinoma. J. Clin. Endocrinol. Metab., Sep 2006; 91: 3584 - 3591.	Abstract
AP7807a ACVRL1 Antibody (N-term)	Ming-Jiun Yu, et al. Proteomic analysis of apical and basolateral plasma membranes of rat renal collecting duct cells Mol. Cell. Proteomics, Aug 2006; Epub ahead of print.	Abstract
AP7908a MEKK2 Antibody (N-term)	Jared A. Gollob et al. Gene Expression Changes and Signaling Events Associated with the Direct Antimelanoma Effect of IFN- . Cancer Res., Oct 2005; 65: 8869 - 8877.	Abstract
AP7910a MEKK4 Antibody (C-term)	Chung Kai Wong et al. The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms. J. Biol. Chem., Sep 2004; 279: 39366 - 39373.	Abstract Full Article
AP7910a MEKK4 Antibody (C-term)	Wen Luo et al. Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation. J. Biol. Chem., Sep 2003; 278: 37451 - 37458.	Abstract Full Article
AP7947a SGK2 Antibody (N-term)	Fanyin Meng et al. IL-6 activates serum and glucocorticoid kinase via p38 mitogen-activated protein kinase pathway. Am. J. Physiol. Cell Physiol., Oct 2005; 289: C971 - C981.	Abstract
AP7947a SGK2 Antibody (N-term)	Fanyin Meng et al. Interleukin-6 activates Serum and Glucocorticoid Kinase via a p38 Mitogen Activated Protein Kinase pathway. Am J Physiol Cell Physiol, May 2005; 10.1152/ajpcell.00081.2005.	Abstract
AP7949a SGK3 Antibody (N-term)	T. Okada et al. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis: The Allelic Difference Provides Novel Insights into Hair Follicle Biology. Am. J. Pathol., Apr 2006; 168: 1119 - 1133.	Abstract
AP7949b SGK3 Antibody (Center)	Fanyin Meng et al. Interleukin-6 activates Serum and Glucocorticoid Kinase via a p38 Mitogen Activated Protein Kinase pathway. Am J Physiol Cell Physiol, May 2005; 10.1152/ajpcell.00081.2005.	Abstract
AP7968c SPAK Antibody (Center)	Carole M. Liedtke et al. Role for Protein Phosphatase 2A in the Regulation of Calu-3 Epithelial Na⁺-K⁺-2Cl^-, Type 1 Co-transport Function. J. Biol. Chem., Jul 2005; 280: 25491 - 25498.	Abstract
AP8004a HGK Antibody (C-term)	Bouzakri, K. et al. MAP4K4 Gene Silencing in Human Skeletal Muscle Prevents Tumor Necrosis Factor-{alpha}-induced Insulin Resistance. J. Biol. Chem. 2007. 282(11): 8110-8122.	Abstract
AP8009a p70 S6Kbeta Antibody (C-term)	Rebecca Cruz et al. S6 kinase 2 potentiates interleukin-3-driven cell proliferation. J. Leukoc. Biol., Oct 2005; 10.1189/jlb.0405225.	Abstract
AP8044b PLK3 Antibody (C-term)	Hong Zhang et al. B23/Nucleophosmin Serine 4 Phosphorylation Mediates Mitotic Functions of Polo-like Kinase 1. J. Biol. Chem., Aug 2004; 279: 35726 - 35734.	Abstract Full Article
AP8051b BRD4 Antibody (C-term)	Kurg, R., et al. Association of Bovine Papillomavirus E2 Protein with Nuclear Structures In Vivo. J. Virol. 2005. 79(16): 10528 - 10539.	Abstract
AP8051b BRD4 Antibody (C-term)	Reet Kurg et al. Characterization of the functional activities of the Bovine Papillomavirus type 1 E2 protein "single-chain" heterodimers. J. Virol., Aug 2006; [Epub ahead of print].	Abstract
AP8051b BRD4 Antibody (C-term)	Reet Kurg et al. Association of Bovine Papillomavirus E2 Protein with Nuclear Structures In Vivo. J. Virol., Aug 2005; 79: 10528 - 10539.	Abstract
AP8066a ARK5 Antibody (N-term)	Niesler, C.U., et al. Muscle: The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis. Exp. Physiol. 2007. 92:207-217.	Abstract
AP8066a ARK5 Antibody (N-term)	Carola U. Niesler et al. The changing AMPK expression profile in differentiating skeletal muscle myoblast cells helps confer increasing resistance to apoptosis. Exp. Physiol., Aug 2006; [Epub ahead of print].	Abstract
AP8093a PCK1 Antibody (N-term)	Sylvie Franckhauser et al. Adipose Overexpression of Phosphoenolpyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity. Diabetes, Feb 2006; 55: 273 - 280.	Abstract
AP8093b PCK1 Antibody (C-term)	Sylvie Franckhauser et al. Adipose Overexpression of Phosphoenolpyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity. Diabetes, Feb 2006; 55: 273 - 280.	Abstract
AP8135b PFKP Antibody (C-term)	Lars C. Moeller et al. Cytosolic Action of Thyroid Hormone Leads to Induction of HIF-1 and Glycolytic Genes. Mol. Endocrinol., Jul 2005; 10.1210/me.2004-0542.	Abstract
AP8154c PFKFB4 Antibody (Center)	Roy Blum, et al. Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1, Causing Glycolysis Shutdown and Cell Death. Cancer Res., Feb 2005; 65: 999 - 1006.	Abstract
AP8445a MKP3 Antibody	Aaron K. Olson et al. Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. Am. J. Physiol. Heart Circ. Physiol., Apr 2006; 290: H1587 - H1595.	Abstract

Acetylation & Methylation

Product	Citation
AM1194a PRDM2 (RIZ1) Antibody	Tobias Carling et al. A Histone Methyltransferase Is Required for Maximal Response to Female Sex Hormones. Mol. Cell. Biol., Aug 2004; 24: 7032 - 7042	Abstract Full Article
AP1034a Dnmt3a Antibody	Feng J. et al. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15;79(6):734-46.	Abstract
AP1034a Dnmt3a Antibody	Koturbash I. et al. Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo. Oncogene, 2006 Mar 13.	Abstract
AP1034a Dnmt3a Antibody	Igor Pogribny et al. Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus. Mol. Cancer Res., Oct 2005; 3: 553 - 561.	Abstract
AP1034a Dnmt3a Antibody	V.P. Tryndyak et al. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis, Aug 2006; 27: 1713 - 1720.	Abstract
AP1035a Dnmt3b Antibody	Koturbash I. et al. Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo. Oncogene, 2006 Mar 13	Abstract
AP1035a Dnmt3b Antibody	Feng J. et al. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005 Mar 15;79(6):734-46.	Abstract
AP1035a Dnmt3b Antibody	Igor Pogribny et al. Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus. Mol. Cancer Res., Oct 2005; 3: 553 - 561.	Abstract
AP1035a Dnmt3b Antibody	Bodo Brueckner et al. Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases. Cancer Res., Jul 2005; 65: 6305 - 6311.	Abstract
AP1035a Dnmt3b Antibody	V.P. Tryndyak et al. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis, Aug 2006; 27: 1713 - 1720.	Abstract
AP1036b MBD1 Antibody (C-term)	Emilie Auriol et al. Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. Nucleic Acids Res., Jul 2005; 33: 4243 - 4254.	Abstract
AP1067a MBD2 Antibody (N-term)	Koturbash I. et al. Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo. Oncogene, 2006 Mar 13.	Abstract
AP1067b MBD2 Antibody (C-term)	Koturbash I. et al. Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo. Oncogene, 2006 Mar 13.	Abstract
AP1109a HDAC9 Antibody (N-term)	Xiaobing Deng, et al. Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation. J. Biol. Chem., Feb 2005; 280: 4894 - 4905.	Abstract
AP1195a SET1 Antibody (N-term)	Jeong-Heon Lee et al. CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex. J. Biol. Chem., Dec 2005; 280: 41725 - 41731.	Abstract
AP1195b SET1 Antibody (C-term)	Jeong-Heon Lee et al. CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex. J. Biol. Chem., Dec 2005; 280: 41725 - 41731	Abstract
AP1198a DOT1L Antibody (N-term)	Bitoun, E. et al. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum. Mol. Genet. 2007; 16:92-106.	Abstract

Other Protein Modifications

Product	Citation
AP1503b Human TLR3 Antibody (N-term )	Nessa BN. et al. Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells. Psychiatry Clin Neurosci, 2006 Apr;60 Suppl 1:S27-33.	Abstract
AP2316a GGA1 Antibody (N-term )	Christine A. F. et al. GGA1 Acts as a Spatial Switch Altering Amyloid Precursor Protein Trafficking and ProcessingJ. Neurosci., Sep 2006; 26: 9913 - 9922.	Abstract
AP2415a ZMPSTE24 Antibody (Center )	Corrigan DP et al. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. Biochem J. 2004 Oct 13; [Epub ahead of print]	Abstract Full Article
AP2415a ZMPSTE24 Antibody (Center )	K Makar et al. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Nature Immunology, Dec 2003; 4(12): 1183 – 1190.	Abstract Full Article
AP2512c EZH2 Antibody (Center)	Zongxiang Zhou et al. Synergy of p53 and Rb Deficiency in a Conditional Mouse Model for Metastatic Prostate Cancer. Cancer Res., Aug 2006; 66: 7889 - 7898.	Abstract
AP2536b FACL4 Antibody (Center )	Thomas Simmen et al. PACS-2 controls endoplasmic reticulum–mitochondria communication and Bid-mediated apoptosis. EMBO J., Feb 2005; 24: 717 - 729.	Abstract

Cellular Function & Disease

Product	Citation
AP1303a Bcl-2 BH3 Domain Antibody	Deng, X., et al. Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival. Mol. Cell. Biol. 2006. 26: 4421 - 4434.	Abstract Full Article
AP1303a Bcl-2 BH3 Domain Antibody	Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival. Xingming Deng et al. Mol. Cell. Biol. Jun 2006; 26: 4421 - 4434.
AP1303a Bcl-2 BH3 Domain Antibody	Xiaobo Lei et al. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB J. 2006; 20: 2147-2149
AP1304a Bcl-G BH3 Domain Antibody	Benito, A. et al. A Novel Role for Proline- and Acid-rich Basic Region Leucine Zipper (PAR bZIP) Proteins in the Transcriptional Regulation of a BH3-only Proapoptotic Gene. J. Biol. Chem. 2006. 281: 38351 - 38357.	Abstract Full Article
AP1310a Bok BH3 Domain Antibody	Yakolev, A.G., et al. BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis. J. Biol. Chem. 2004. 279: 28367 - 28374.	Abstract Full Article
AP1310a Bok BH3 Domain Antibody	BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis. Alexander G. Yakovlev et al. J. Biol. Chem. Jul 2004; 279: 28367 - 28374.
AP1312a Mcl-1 BH3 Domain Antibody	Yamane, T., et al. Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal. Proc. Natl. Acad. Sci. U S A. 2005. 102: 3312 - 3317.	Abstract Full Article
AP1312a Mcl-1 BH3 Domain Antibody	Johnson, A.J., et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood. 2006. 108: 1334 - 1338.	Abstract
AP1312a Mcl-1 BH3 Domain Antibody	Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Amy J. Johnson et al. Blood. Aug 2006; 108: 1334 - 1338.
AP1312a Mcl-1 BH3 Domain Antibody	Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal. Toshiyuki Yamane et al. Proc. Natl. Acad. Sci. U S A. Mar 2005; 102: 3312 - 3317.
AP1332a HtrA3 Antibody (N-term)	Grau, S., et al. Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc. Natl. Acad. Sci. U S A. Apr 2005; 102: 6021 - 6026.	Abstract Full Article
AP1332a HtrA3 Antibody (N-term)	Implications of the serine protease HtrA1 in amyloid precursor protein processing. Sandra Grau et al. Proc. Natl. Acad. Sci. U S A. Apr 2005; 102: 6021 - 6026.
AP1503a Human TLR3 Antibody (C-term)	Nessa BN. et al. Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells. Psychiatry Clin Neurosci, 2006 Apr;60 Suppl 1:S27-33.	Abstract
AP1802a Autophagy APG8b (MAP1LC3B) Antibody (N-term)	Cao, Y., et al. Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis. J. Biol. Chem. 2006. 281: 20483 - 20493.	Abstract Full Article
AP1802a Autophagy APG8b (MAP1LC3B) Antibody (N-term)	Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis. Yi Cao et al. J. Biol. Chem. Jul 2006; 281: 20483 - 20493.
AP2004b BMPR1A Antibody (C-term)	Gregor Pache et al. Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Am. J. Physiol. Renal. Physiol., Sep 2006; 291: F654 - F662.	Abstract
AP2005a BMPR1B Antibody (N-term K15)	Sehgal, P.B. et al. Dysfunction of Golgi tethers, SNAREs and SNAPs in monocrotaline-induced pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. March, 2007. doi:10.1152/ajplung.00463.2006	Abstract
AP2014b NT5E Antibody (C-term)	Jennifer L. Macdonald et al. A simplified method for the preparation of detergent-free lipid rafts. J. Lipid Res., May 2005; 46: 1061 - 1067.	Abstract
AP2053a SLUG Antibody (Center)	Bardeesy, N. et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes & Dev. 2006. 20: 3130 - 3146.	Abstract
AP2053a SLUG Antibody (Center)	Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Nabeel Bardeesy et al. Genes & Dev. Nov 2006; 20: 3130 - 3146.
AP2054a SNAIL Antibody (N-term D24)	An S. De Vriese et al. Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. Nephrol. Dial. Transplant., Sep 2006; 21: 2549 - 2555.	Abstract
AP6000a SARS virus Sn Antibody	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6000a SARS virus Sn Antibody	Milosz Faber et al. A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARS-CoV-neutralizing antibodies. J. Gen. Virol., May 2005; 86: 1435 - 1440.	Abstract
AP6000a SARS virus Sn Antibody AP6000b SARS virus Sm Antibody	Natalia Pogrebnyak et al. Severe acute respiratory syndrome (SARS) S protein production in plants: Development of recombinant vaccine. PNAS, Jun 2005; 102: 9062 - 9067.	Abstract
AP6000b SARS virus Sm Antibody	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6000b SARS virus Sm Antibody	Naoto Ito, et al. Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is a Viral Structural Protein. J. Virol., Mar 2005; 79: 3182 - 3186.	Abstract
AP6000b SARS virus Sm Antibody	Hyun Chul Song et al. Synthesis and Characterization of a Native, Oligomeric Form of Recombinant Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein. J. Virol., Oct 2004; 78: 10328 - 10335.	Abstract
AP6000b SARS virus Sm Antibody	Jong-Soo Lee et al. Mucosal Immunization with Surface-Displayed Severe Acute Respiratory Syndrome Coronavirus Spike Protein on Lactobacillus casei Induces Neutralizing Antibodies in Mice. J. Virol., Apr 2006; 80: 4079 - 4087.	Abstract
AP6001a SARS virus PUP1 Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6001b SARS virus PUP1 Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6002a SARS virus PUP2 Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6002b SARS virus PUP2 Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6004a SARS virus PUP4 Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6004b SARS virus PUP4 Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6005a SARS virus PUP5 Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6005b SARS virus PUP5 Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6006a SARS virus PUP6 Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6006b SARS virus PUP6 Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6008a SARS virus PUPM Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6008b SARS virus PUPM Antibody (C-term)	Huang, C. et al. Severe Acute Respiratory Syndrome Coronavirus Accessory Protein 6 Is a Virion-Associated Protein and Is Released from 6 Protein-Expressing Cells. J. Virol. March 2007. doi:10.1128/JVI.02307-06.	Abstract
AP6008b SARS virus PUPM Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6008b SARS virus PUPM Antibody (C-term)	Cheng Huang et al. Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is Released in Membranous Structures from 3a Protein-Expressing Cells and Infected Cells. J. Virol., Jan 2006; 80: 210 - 217	Abstract
AP6008b SARS virus PUPM Antibody (C-term)	Chen Huang et al. Severe Acute Respiratory Syndrome Coronavirus 7a Accessory Protein Is a Viral Structural Protein. J. Virol., Aug 2006; 80: 7287 - 7294.	Abstract
AP6009b SARS virus Spike Antibody (N-term D204)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6009c SARS virus Spike Antibody (Center K439)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6009h SARS virus Spike Antibody (C-term D1135)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6010a SARS Virus SPIKE(E2GP) Antibody (N-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6010b SARS Virus SPIKE(E2GP) Antibody (C-term)	Chan, W.S., et al. Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS). Mod. Pathol. 2005. 18(11):1432 - 1439.	Abstract Full Article
AP6010b SARS Virus SPIKE(E2GP) Antibody (C-term)	Jong-Soo Lee et al. Mucosal Immunization with Surface-Displayed Severe Acute Respiratory Syndrome Coronavirus Spike Protein on Lactobacillus casei Induces Neutralizing Antibodies in Mice. J. Virol., Apr 2006; 80: 4079 - 4087.	Abstract
AP6112a ABCB4 Antibody (Center)	Gautier, T., et al. Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein. J. Lipid Res. 2007. 48: 30 - 40.	Abstract
AP6112a ABCB4 Antibody (Center)	Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein. Thomas Gautier et al. J. Lipid Res. Jan 2007; 48: 30 - 40.
AP6133a GREMLIN Antibody (C-term)	Natasha Y. Frank, et al. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J. Cell Biol., Oct 2006; 10.1083/jcb.200511036.	Abstract
AP6138a EDG2 Antibody (N-term)	Ahmed Boucharaba et al.The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases. PNAS, Jun 2006; 103: 9643 - 9648.	Abstract
AP6190a MLLT3 Antibody (C-term K486)	Bitoun, E. et al. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum. Mol. Genet. 2007; 16:92-106.	Abstract
AP6224a NRG3 Antibody (Center)	Beatrice Howard et al. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes & Dev., Sep 2005; 19: 2078 - 2090.	Abstract
AP6226a OAS1 Antibody (C-term)	Van den Pol, A.N., et al. Cytomegalovirus Induces Interferon-Stimulated Gene Expression and Is Attenuated by Interferon in the Developing Brain. J. Virol. 2007. 81: 332 - 348.	Abstract
AP6226a OAS1 Antibody (C-term)	Kanda, N. et al. Prolactin Enhances Interferon-γ-Induced Production of CXCL9, CXCL10, and CXCL11 in Human Keratinocytes. Endocrinology, January 2007. doi:10.1210/en.2006-1639.	Abstract
AP6226a OAS1 Antibody (C-term)	Alimirah, F., et al. IFI16 in Human Prostate Cancer. Mol. Cancer Res. March 2007. doi: 10.1158/1541-7786.MCR-06-0269.	Abstract
AP6226a OAS1 Antibody (C-term)	Han, J. et al. A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L. J. Virol. March 2007. doi:10.1128/JVI.01857-06.	Abstract
AP6226a OAS1 Antibody (C-term)	Cytomegalovirus Induces Interferon-Stimulated Gene Expression and Is Attenuated by Interferon in the Developing Brain. Anthony N. van den Pol et al. J. Virol. Jan 2007; 81: 332 - 348.
AP6226a OAS1 Antibody (C-term)	Jongdae Lee et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. PNAS, Feb 2006; 103: 1828 - 1833.	Abstract

Tag Specific

Product	Citation
AM1007a Myc Tag Antibody	Jun Hang et al. Identification of a Novel Recognition Sequence for Fibronectin within the NH2-terminal -Sandwich Domain of Tissue Transglutaminase. J. Biol. Chem., Jun 2005; 280: 23675 - 23683.	Abstract
AM1009a GFP Tag Antibody	William H. Witola et al. Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi Apparatus. J. Biol. Chem., Jul 2006; 281: 21305 - 21311.	Abstract
AM1009a GFP Tag Antibody	Geert J.P.L. Kops et al. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J. Cell Biol., Apr 2005; 169: 49 - 60.	Abstract
AP1012a HA Tag Antibody	Cellular FLICE-Inhibitory Protein Down-regulation Contributes to Celecoxib-Induced Apoptosis in Human Lung Cancer Cells. Xiangguo Liu et al. Cancer Res. Dec 2006; 66: 11115 - 11119.

Custom Services - Peptide Synthesis

Product	Citation
Peptide Synthesis	Wang, S., et al. In Vitro Fluorescence Anisotropy Analysis of the Interaction of Full-length SRC1a with Estrogen Receptors alpha and beta Supports an Active Displacement Model for Coregulator Utilization. J. Biol. Chem. 2007. 282: 2765 - 2775.	Abstract
Peptide Synthesis	Chang, I.F., et al. Proteomic Characterization of Evolutionarily Conserved and Variable Proteins of Arabidopsis Cytosolic Ribosomes. Plant Physiol. 2005. 137: 848 - 862.	Abstract Full Article
Peptide Synthesis	Proteomic Characterization of Evolutionarily Conserved and Variable Proteins of Arabidopsis Cytosolic Ribosomes. Ing-Feng Chang, et al. Plant Physiology. Mar 2005; 137: 848 - 862.
Peptide Synthesis	In Vitro fluorescence anisotropy analysis of the interaction of full-length SRC1a with estrogen receptors and supports an active displacement model for coregulator utilization. Stanley Wang et al. J. Biol. Chem. Nov 2006; 10.1074/jbc.M607531200.
Custom Peptide Synthesis	Dan Zhao et al. Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Am J Physiol Renal Physiol., Mar 2006; 10.1152/ajprenal.00011.2006.	Abstract
Custom Peptide Synthesis	Brian Coblitz et al. C-terminal Recognition by 14-3-3 Proteins for Surface Expression of Membrane Receptors. J. Biol. Chem., Oct 2005; 280: 36263 - 36272.	Abstract
Custom Peptide Synthesis	Sammy CS Chow et al. Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients. J. Clin. Pathol., Feb 2006; 10.1136/jcp.2005.029868.	Abstract
Custom Peptide Synthesis	Jun Dai, et al. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes & Dev., Feb 2005; 19: 472 - 488.	Abstract
Custom Peptide Synthesis	Irina Dulubova et al. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. PNAS, Jan 2003; 100: 32 - 37.	Abstract Full Article
Custom Peptide Synthesis	Dai, Jun and Sultan, Sammy and Taylor, Stephen S. and Higgins, Jonathan M.G. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaph