Cellular Function and Disease
Posttranslational modifications functionally imprint protein
phenotype via changes in protein structure and function and are
thereby a key for properly tasking proteins within the cell. In
addition, specific protein-protein interactions can control the
expression of intracellular phenotype. The proper modification of
proteins either through covalent modification or protein-protein
interactions is a key aspect determining cellular health and disease.
Comparing protein profiles from normal cells with those in clinical
pathology is expected to reveal new insights into the molecular
mechanisms associated with diverse disease-related processes such a
carcinogenesis, apoptosis, autoimmunity, viral infections, and
neurological and degenerative disorders. |
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