Protein Partitioning
Ubiquitin (Ub) marks proteins for proteolytic degradation by the 26S
proteasome. Substrate selection, and covalent attachment of Ub are
vital to regulate concentrations of regulatory proteins involved in
processes such as the cell cycle, apoptosis, signal transduction, and
DNA replication/repair. Mutation or inactivation of Ub, associated
enzymes, and substrates correlate with a diverse set of cellular
pathologies.
Covalent modification by SUMO modulates processes such as protein
localization, transcription, nucleocytoplasmic signaling and
transport, genomic replication, and viral reproduction. Targets
include p53, transcription factors, topoisomerases, histone
deacetylases, and signal transduction molecules, among many others.
Link to SumoplotTM to determine potential sumoylation sites in your
protein.
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