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In This Issue:
Review Article
- The Ubiquitin Proteasome Pathway: a Ubiquitous Drug Target?
Featured Article - EpiShot™: a Rational Approach for Epitope Prediction
Product Update - New Products for Your Research
Customer Corner - Special Offer: $20 Starbucks Gift Card, Request Our Catalog
Tech Corner - Blocking Peptides, Citations, Kinome Express™ and Web Links
Company Info - Latest News of Abgent Research, Distributors, Parkinson Disease
Upcoming Meetings - AACR 2006 in D.C., UCLA, Scripps Research Institute
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The Ubiquitin Proteasome Pathway: a ubiquitous drug target? |
Review Article
- A Nobel prize and an FDA-approved drug later, the ubiquitin proteasome pathway is one of the hottest fields at the moment. As the principal
mechanism for protein catabolism in the mammalian cytosol and nucleus, the pathway affects a wide variety of cellular processes through E1
activating enzymes, E2/E3 ligases, and deubiquitination enzymes.
This review will highlight some of the latest advances in this field and its potential impact on clinicians.
Read Full Article |
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Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts ™ Dr. Lianping Xing and his
collaborators from the University of Rochester and NCI in Bethesda described that osteoblast differentiation is inhibited by TNF via the
ubiquitin proteasome pathway. The upregulated Smurf1, an E3 ubiquitin ligase, increased degradation of the Runx2, a critical transcription
factor for bone-forming osteoblast activities. The study used Abgent™s antibody to Smurf1
(Cat #AP2104a)
Review Data
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Ubiquitination Product Line
™ Check out our antibody products for studying the ubiquitin proteasome pathway.
View Flier
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EpiShot™: a Rational Approach for Epitope Prediction |
Featured Article - Antibodies
are powerful and universal tools in today™s biology research. Outcomes of multiple-year projects often depend on the quality of the antibodies.
Although producing an antibody is as easy as subcloning a gene, there are a number of conditions that go into designing the antigen and producing
the antibody. Understanding those issues while working with the antibody production team enhances the likelihood of success. This multi-field
expertise has been offered to our customers through our EpiShot™ epitope prediction procedure, and is now the objective of this review.
Read Full Article
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The Role of Branchial Carbonic
Anhydrase in Acid-base Regulation in Rainbow Trout ™ A project led by Dr. S.F. Perry from the University of Ottawa (Canada) described the key catalytic activity and cellular localization of the
cytoplasmic carbonic anhydrase (tCAc) in regulating the acid-base balance in rainbow trout. The custom-made antibody produced at
Abgent has generated valuable data.
Review Data
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Custom Antibody Production
™ Abgent™s expertise in polyclonal and monoclonal antibody production is available for your on-going scientific research.
A talk with our team prior starting your antibody production can save you from recurrent mistakes in antigen design. Our
flier helps you to choose the project that best fits your needs.
View Flier
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Product Update |
New Products
50 Phospho-Specific Antibodies: AKT1(Y326), APP(S198), IRAK1(S376)
50 RNA Interference Antibodies: Dicer1, ElF2C2, NUP54, RENT1, SF3A1
Couplage™ Bioconjugation Kits: stable activation chemistry for biomolecules
Hot Products
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Tech Corner |
Q:
How do I know whether the bands I detect on my Western blot are specific?
A: The antigen used to raise the antibody can be used as
an inhibitor to compete for antibody binding with the endogenous target. Although more validation may be required, adding a blocking
peptide to the antibody preparation can solve questions about a noisy Western blot. Abgent offers Blocking Peptides complementary
to Antibody products.
View our Blocking Peptide protocol.
Product Application: Check out our latest product citations:
ADK2, RET, SGK3, SMURF1,™
Scientific Tools: Use our Kinome Express™
to check for the expression pattern of kinases in human tissues
and for known substrates.
Helpful Web Links:
Visit web sites with proteomics analysis tools, protein databases, or for the latest info on pharmaceutical targets in clinical trials.
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| Upcoming Meetings |
Meet Abgent staff and worldwide representatives at the following conferences:
- Apr 2-5 AACR 2006, Washington, DC at Booth #1746
- Apr 13 UCLA, California
- May 16 The Scripps Research Institute, CA
- Worldwide Meetings
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Abgent, Inc.
10239 Flanders Court, San Diego, CA 92121
1.888.SEL.PABS
858-622-0099
858-622-0609 fax
Email: info@abgent.com
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