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In This Issue:
Review Article - Autophagy, a Survival Guide
Featured Article - Protein Methyltransferases: Markers of Dietary Carcinogenesis
Product Update - New Products for Your Research
Customer Corner - Request Our Catalog, Starbucks Gift Card, Free Peptide
Tech Corner - Peptide Solubility, Citations, KinoScope™ and Web Links
Company Info - Latest News of Abgent Research, Distributors, Milestone
Upcoming Meetings - Neuroscience 06, ASCB 06, Harvard, NIH
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| Autophagy, A Survival Guide |
Review Article - Autophagy is a self-digestion process central to development, aging, immunity and cell death. This process is important to maintain a well-controlled balance between anabolism and catabolism in order to have normal cell growth and development. It plays an essential role during starvation, cellular differentiation, apoptosis, and in preventing some types of cancer. The nexus between autophagy and disease is of growing interest to basic researchers and pharmaceutical companies. Read Full Article |
| Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis – Dr. Susan Cotman and her collaborators at the Massachusetts General Hospital, Boston and Albert Einstein College of Medicine, Bronx described in a mouse model that disruption of autophagy in juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) causes lysosomal accumulation of the subunit c of the ATPase F0 complex. The study used Abgent’s antibody to APG8b/MAP-LC3 (Cat.# AP1802a), a strong marker for autophagy Review Data
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Autophagy Product Line – Check out our antibody products for studying the autophagy pathway. View Flyer.
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| Protein Methyltransferases: Markers of Dietary Carcinogenesis |
Featured Article - Like phosphorylation and ubiquitination, protein methylation is poised to emerge as a posttranslational modification of great importance to tumor biology. Lysine protein methyltransferases (PRDMs), which contains a PR/SET domain, have defined a new tumor suppressor archetype by linking cellular mechanism of carcinogenesis to organism dietary intake. The strong probability that dietary nutrients directly influence enzyme activities has significant bearing for public health policy and private investment in dietetic and pharmaceutical interventions. How a hamburger can imbalance your methyltransferase pool is now the objective of this review. Read Full Article
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Effect of Radiation and Tamoxifen on Carcinogenesis – Two collaborative projects led by Drs. O. Kovalchuk and I. Pogribny at the NCI-NIH in Bethesda, MD and the Natl Ctr for Toxicological Research in Jefferson, AR, respectively, described the epigenetic effects of radiation and tamoxifen treatments in animal models. Overall DNA hypomethylation observed during carcinogenesis may relate to lower protein level for the DNA methyltransferases, the main enzymes responsible for maintaining DNA methylation patterns. Review Data
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Methylation Product Line – Check out our antibody products for studying the methylation pathway. View Flyer. |
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Product Update
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| New Products
50 Autophagy Antibodies: APGs, BECN1, RAB24, RGS19
300 Kinase Profiling Phospho Peptides: ABL, CDKs, Cdc, p53, Rb, Smads
10 Tag Specific Antibodies: B Tag, Flag, GFP, GST, HA, His, Myc, VSV-g
Hot Products
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Check out our product lines for protein modification research:
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| Customer Corner |
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NEW 2006-08 CATALOG
Request Abgent Catalog and Technical Reference
Special Offer: Get a $20 Starbucks card when you update your contact information. Click the link at the bottom of this email.
Promotion: Order a bioconjugation Couplage™ Kit, get a catalog peptide for free! (SP Cat. No.)
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| Tech Corner |
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Q: My peptide is not soluble in water. What can I do?
A: Solubility of peptides depends upon peptide sequence. First, try distilled water and sonication at 1-10 mg/ml. Then, count the number of basic residues (K, R, H and free N-term) versus acidic residues (E, D and free C-term). If there are more basic residues, add 0.1M acetic acid drop-wise until solubilized. If there are more acidic residues, add 0.1M ammonium hydroxide drop-wise until solubilized. When using buffers, do not add salts until the peptide is in solution. Last, try organic solvents such as DMSO, acetonitrile, or DMF.
Product Application: Check out our latest product citations: USP2, Piasy1, DAPK2, ARK5…
Scientific Tool: Use our KinoScope™ kinase inhibitor charts to select inhibitors to specific kinase pathways.
Helpful Web Links: Visit web sites with proteomics analysis tools, protein databases, or for the latest info on pharmaceutical targets in clinical trials. Here
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| Company Info |
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Abgent Research: Renowned autophagy authority, Noboru Mizushima at Tokyo Medical and Dental University in Japan, has agreed to validate Abgent’s entire line of autophagy-related antibodies. The collaboration is supported by Cosmo Bio, a distributor of Abgent products in Japan.
Abgent Business: Abgent’s Hervé Le Calvez was the featured speaker at Cosmo Bio’s 9th Annual Cosmo Focus Meeting in Japan, where he introduced audiences in Tokyo and Osaka to Abgent’s latest product lines.
Abgent Distributors: Abgent Europe, the European office of Abgent, Inc. now directly serves the Netherlands, Belgium, and Luxembourg.
  
View All Abgent Distributors
Abgent Milestone: On August 5th, Abgent celebrated five years of providing high-quality reagents to life scientists worldwide. Our thanks to all whose work and support have made Abgent a success.
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| Upcoming Meetings |
Meet Abgent staff and worldwide representatives at the following conferences:
- Sep 27-28 Harvard Medical School, Boston, Booth #324
- Oct 14-18 Neuroscience 2006, Atlanta, Booth #2028
- Oct 19-20 NIH, Bethesda, Booth #258
- Dec 9-13 ASCB 2006, San Diego, Booth #1425
- Worldwide Meetings
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Abgent, Inc.
6310 Nancy Ridge Dr.
Suite 106
San Diego, CA 92121
1.888.SEL.PABS
858-622-0099
858-622-0609 fax
Email: info@abgent.com
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