Chromatin Directed Transcriptional Regulation Pathways

Acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination, and methylation of histones play a critical role in regulating chromatin structure and gene expression.  Modification of specific residues in histone proteins induces conformational changes by either destabilizing nucleosomes, thereby allowing transcription factors to access recognition elements of the DNA, or contrarily by resealing the chromosomal package, leading to transcription repression.  Abgent now offers 80 antibodies targeting chromatin modifying enzymes to help elucidate these critical processes.

Histone Demethylases

We have developed eight new antibodies directed against histone demethylating enzymes. Recent findings show that methylation is a reversible covalent modification of chromatin, with methyl groups subject to removal from histones by novel JMJD-domain-containing histone demethylation enzymes.

Abgent develops primary antibodies and provides first-in-class custom peptide synthesis & antibody development. Our antibodies are widely used for Autophagy, Apoptosis, Protein Partitioning, Phosphorylation, Cell Function & Disease & Gene Regulation research. Synthesis of difficult peptides is a core competency. High-quality, rapid turnaround & personal support is guaranteed.