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In This Issue:
Review Article - HDACs: Regulators of Genomic Free Speech
Featured Article - Kinases in Neurodegenerative Diseases
Product Update - New Products for Your Research
Customer Corner - Request New Catalog, Special Offers on Antibody Products
Tech Corner - Antibody Storage, Citations, SUMOplot™ and Web Links
Company Info - Latest News of Abgent Research, Collaborations and Distributors
Upcoming Meetings - ASCB 06, UC San Francisco, UC San Diego
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| HDACs: Regulators of Genomic Free Speech |
Review Article - Histone deacetylases (HDACs) are a family of enzymes whose primary function is to remove the acetyl group from histones, which causes the surrounding DNA to wind more tightly around the histone, thus denying the cell’s transcriptional machinery access to genetic material. Because HDACs play a critical role in gene expression, its dysfunction and inappropriate recruitment have been implicated in numerous diseases, ranging from leukemia to AIDS. Thus, new and previously approved drugs that inhibit HDACs have become the subject of ongoing clinical trials. Read Full Article
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Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation – Dr. Eileen Friedman and her collaborators at Upstate Medical University, State University of New York, Syracuse described in a mouse myoblast model that myogenic transcription factors are regulated by class II HDACs via Mirk kinase signaling. The study used Abgent’s antibody to HDAC9/MITR (Cat.# AP1109a) to monitor MITR cellular distribution. Review Data
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Acetylation Product Line – Check out our antibody products for studying histone acetylation. Visit our website or contact us to receive our Methylation & Acetylation flier. View Flyer.
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| Kinases in Neurodegenerative Diseases |
Featured Article - Protein kinases represent as much as thirty percent of all protein targets under investigation by pharmaceutical companies. Recent successful launches of cancer-targeted drugs with kinase inhibition as the mode of action demonstrate the ability to deliver kinase inhibitors as drugs with the appropriate selectivity, potency, and pharmacokinetic properties. To date, kinase brain research, however, has not yet delivered many candidates for treating neurodegenerative disorders such as Alzheimer and Parkinson diseases. The latest reports of potential treatments of brain disorders by using kinase inhibitors are reviewed. Read Full Article
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LRRK2 in Parkinson’s Disease and Dementia with Lewy Bodies – A project led by Dr. S. Chen at Case Western University in Cleveland, OH described the use of antibodies to label brainstem and cortical Lewy bodies, the pathological hallmarks of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), respectively. They demonstrated that LRRK2 is a component of Lewy bodies in both PD and DLB, and therefore plays an important role in the Lewy body formation and disease pathogenesis. Review Data
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The Brain Kinome – The Brain Kinome is a phylogenetic tree created by Abgent bioinformatics staff to illustrate the role of kinases in brain disorders. Contact us now for your free wall poster! View Flyer. |
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Product Update
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| New Products
50 Cell and Tissue Lysates: CHO, HeLa, 293, Jurkat, SKBR3, THP1
75 RNAi Antibodies: STK38, RPC5, TAOK1
180 Phospho-Specific antibodies: CDC25A, CDKs, FGFR, IKKy, MET, NFkB, RADs, PLM
Hot Products
* Offers valid in the USA. Conditions may vary for other countries, please contact your Abgent distributor for details on promotions.
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Check out our product lines for protein modification research:
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| Customer Corner |
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NEW 2006-08 CATALOG
Request Abgent Catalog and Technical Reference
Special Offer*: Get 50% OFF on our Tag Specific antibodies until Mar 15, 2007! Use promotional code ABG-TAG06.
New Year Promotion*: Order 2 antibodies, get the 3rd for free until Feb 15, 2007!
Use promotional code ABG-34206.
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| Tech Corner |
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Q: How do I store my antibodies?
A: It is good practice to aliquot your antibodies in small volumes upon receiving. We recommend using multiple aliquots of 20-100 ul for frequent bench work, whereas bulk is stored away in 5-20 ml tubes. Antibodies are robust proteins although multiple freeze-thaw cycles will diminish their properties. They should be frozen at –20°C for long term storage (>1 month), -80°C for crude sera to minimize proteolysis. Small aliquots can be kept at 4°C for frequent use within few days, otherwise at –20°C, especially for crude or partially purified antibodies. Don’t forget that antibodies have general stability properties that can vary from one antibody to another. Stability testing is recommended for unknown antibodies.
Product Application: Check out our latest product citations: Phospho-HGFR, Bcl-2, DYRKB…
Scientific Tool: Use our SUMOplot™ bioinformatic tool to predict sumoylation sites in your protein sequence.
Helpful Web Links: Visit web sites with proteomics analysis tools, protein databases, or for the latest info on pharmaceutical targets in clinical trials. Here
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| Company Info |
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Abgent Research: A selection of Abgent’s angiogenesis signaling pathway antibodies is currently being tested by David Cheresh’s laboratory at the Rebecca and John Moores Cancer Center, UC San Diego, CA. The resulting validation will be available to Abgent’s customers in 2007.
Abgent Business: Abgent’s business model was featured on the front cover of the San Diego Union Tribune in an article about the area’s maturing biotechnology sector. Read article.
Abgent Distributors: MJS BioLynx serves our customers in Canada since 2004. With a French-English bilingual staff, MJS BioLynx is a premium partner to support Abgent customers with technical expertise.
View All Abgent Distributors
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| Upcoming Meetings |
Meet Abgent staff and worldwide representatives at the following conferences:
- Thank you for visiting our booth on Dec 9-13 at ASCB 2006, San Diego, CA
- Feb 1 UC San Francisco, CA
- Feb 8 UC San Diego, CA
- Feb 20-22 BSI Glasgow, UK
- Worldwide Meetings
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Abgent, Inc.
6310 Nancy Ridge Dr.
Suite 106
San Diego, CA 92121
1.888.SEL.PABS
858-622-0099
858-622-0609 fax
Email: info@abgent.com
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