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Citations

Abgent's innovative products and custom services for the study of proteomic modifications rank us as a cited supplier in Nature's 2003 Antibody Technology and 2004 Drug Discovery Features, and in The Scientist's 2003 Cell Signaling Feature. Representative product citations appear in the peer reviewed publications below:

 

Autophagy top
Product Citation  

AP1802a  
APG8b (MAP1LC3B) (N-term)

Jean H. Overmeyer, et al. Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis. Mol. Cancer Res., Jun 2008; 6: 965 - 977.

Abstract

AP1809a  
Autophagy APG4B Antibody (N-term)

Garneau, Hugo, et al. Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. Am J Physiol Gastrointest Liver Physiol 2007 Oct 01;293(4):G758-772.

Abstract

AP1802a  
Autophagy LC3 Antibody (APG8b) (N-term)

Liao, Guanghong, et al. Cholesterol Accumulation Is Associated with Lysosomal Dysfunction and Autophagic Stress in Npc1 / Mouse Brain. Am. J. Pathol. 2007 Sep 01;171(3):962-975.

Abstract
Full Article

AP1802a  
Autophagy LC3 Antibody (APG8b) (N-term)

Cao, Yi, et al. Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis. J. Biol. Chem. 2006 Jul 21;281(29):20483-20493.

Abstract
Full Article

AP1802a  
Autophagy LC3 Antibody (APG8b) (N-term)

Jennifer M. Rosenbluth, et al. A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73. Mol. Cell. Biol., Oct 2008; 28: 5951 - 5964.

Abstract

AP8014b  
Autophagy Kinase PI3KC3 Antibody (C-term)

Chengyu Liang, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006 Jul;8(7):688-99.

Abstract

AP8014a  
Autophagy Kinase PI3KC3 Antibody (N-term)

Chengyu Liang, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006 Jul;8(7):688-99.

Abstract

AP2183b  
Autophagy SQSTM1 (p62) Antibody (C-term)

Jeong-Sun Ju, et al. Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP associated disease. J. Biol. Chem., Oct 2008; 283: 30289 - 30299.

Abstract
Full Article

AP1812b  
Autophagy APG5L Antibody (C-term)

Zhen-Bin Ding, et al. Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma. Cancer Res., Nov 2008; 68: 9167 - 9175.

Abstract
Full Article

AP1813d  
Autophagy APG7L Antibody (C-term)

Zhen-Bin Ding, et al. Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma. Cancer Res., Nov 2008; 68: 9167 - 9175.

Abstract
Full Article

AP1850b  
Autophagy UVRAG Antibody (C-term)

Qiming Sun, et al. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. PNAS, Dec 2008; 105: 19211 - 19216.

Abstract
Full Article
Stem Cell top
Product Citation  

AP1447c  
CDCA8 Antibody (Center)

Fang Xia, et al. A survivin-Ran complex regulates spindle formation in tumor cells. Mol. Cell. Biol., Sep 2008; 28: 5299 - 5311.

Abstract
Apoptosis top
Product Citation  

AP1303a  
Bcl-2 BH3 Domain Antibody

Jennifer Thompson, et al. During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J. Exp. Med., May 2008; 205: 1029 - 1036.

Abstract

AP1303a  
Bcl-2 BH3 Domain Antibody

Victoria Del Gaizo Moore, et al. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood, Feb 2008; 111: 2300 - 2309.

Abstract

AP1308a  
Bim BH3 Domain Antibody

Del Gaizo Moore, Victoria, et al. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood 2008 Feb 15;111(4):2300-2309.

Abstract

AP1319a  
Bik BH3 Domain Antibody

Sass, Gabriele, et al. TNF Pretreatment Interferes with Mitochondrial Apoptosis in the Mouse Liver by A20-Mediated Down-Regulation of Bax. J. Immunol. 2007 Nov 15;179(10):7042-7049.

Abstract

AP1300a  
A1 BH3 Domain Antibody

Gollob, Jared A., et al. Gene Expression Changes and Signaling Events Associated with the Direct Antimelanoma Effect of IFN-{gamma}. Cancer Res. 2005 Oct 01;65(19):8869-8877.

Abstract
Full Article

AP1303a  
Bcl-2 BH3 Domain Antibody

Deng, Xingming, et al. Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival. Mol. Cell. Biol. 2006 Jun 15;26(12):4421-4434.

Abstract
Full Article

AP1304a  
Bcl-G BH3 Domain Antibody

Benito, Adalberto, et al. A Novel Role for Proline- and Acid-rich Basic Region Leucine Zipper (PAR bZIP) Proteins in the Transcriptional Regulation of a BH3-only Proapoptotic Gene. J. Biol. Chem. 2006 Dec 15;281(50):38351-38357.

Abstract
Full Article

AP1310a  
Bok BH3 Domain Antibody

Yakovlev, Alexander G., et al. BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis. J. Biol. Chem. 2004 Jul 02;279(27):28367-28374.

Abstract
Full Article

AP1312a  
Mcl-1 BH3 Domain Antibody

Johnson, Amy J., et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood 2006 Aug 15;108(4):1334-1338.

Abstract
Full Article

AP1312a  
Mcl-1 BH3 Domain Antibody

Yamane, Toshiyuki, et al. Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal. PNAS 2005 Mar 01;102(9):3312-3317.

Abstract
Full Article

AP1303a  
Bcl-2 BH3 Domain Antibody

Xingming Deng, et al. Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. Blood, Oct 2008; 10.1182/blood-2008-06-165134 (E-pub).

Abstract

AP1303a  
Bcl-2 BH3 Domain Antibody

Jie Liu, et al. Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues. Cancer Res., Nov 2008; 68: 8871 - 8880.

Abstract

AP1303a  
Bcl-2 BH3 Domain Antibody

Lei, Xiaobo, et al. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB J 2006 Oct 01;20(12):2147-2149.

Abstract
Full Article
Protein Modification top
Product Citation  

AP7237c  
SPHK1 Antibody (Center)

Sun, Jianxin, et al. FHL2/SLIM3 Decreases Cardiomyocyte Survival by Inhibitory Interaction With Sphingosine Kinase-1. Circ. Res. 2006 Sep 01;99(5):468-476.

Abstract
Full Article

AP7922a  
MST1 Antibody (C-term)

Aixia Ren, et al. Down-regulation of Mammalian Sterile 20-Like Kinase 1 by Heat Shock Protein 70 Mediates Cisplatin Resistance in Prostate Cancer Cells. Cancer Res., Apr 2008; 68: 2266 - 2274.

Abstract

AP7025a  
PKC nu

Jun Chen, et al. Protein Kinase D3 (PKD3) Contributes to Prostate Cancer Cell Growth and Survival Through a PKC/PKD3 Pathway Downstream of Akt and ERK 1/2. Cancer Res., May 2008; 68: 3844 - 3853.

Abstract

AP7144b  
MARK1 (C-term)

Aram F. Hezel, et al. Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms. Mol. Cell. Biol., Apr 2008; 28: 2414 - 2425.

Abstract

AP7144a  
MARK1 (N-term)

Aram F. Hezel, et al. Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms. Mol. Cell. Biol., Apr 2008; 28: 2414 - 2425.

Abstract

AP1282a  
SUMO2 Antibody (C-term)

Yu-Qian Zhang, et al. Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell Biol., Jul 2008; 182: 35 - 39.

Abstract

AP2118a  
UBE2L6 Antibody (N-term)

Mohammad Shahidul Makki, et al. TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. Nucleic Acids Res., Jul 2008; 36: 4067 - 4078.

Abstract

AP7968c  
SPAK (Center)

Laura Smith, et al. PKC[delta] acts upstream of SPAK in the activation of NKCC1 by hyperosmomtic stress in airway epithelial cells. J. Biol. Chem., Aug 2008; 283: 22147 - 22156.

Abstract

AP7097a  
PNCK Antibody (C-term)

Tushar B. Deb, et al. Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. Am J Physiol Cell Physiol, Aug 2008; 295: C365 - C377.

Abstract

AP7040a  
PDK3 Antibody (N-term)

Thomas McFate, et al. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J. Biol. Chem., Aug 2008; 283: 22700 - 22708.

Abstract

AP8004a  
HGK Antibody (C-term)

Reginald L., et al. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes, Aug 2008; 57: 2066 - 2073.

Abstract

AP2118b  
UBE2L6 Antibody (C-term)

Kramer, Oliver H., et al. Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RAR{alpha}. FASEB J 2007 Dec 11;fj.06-8050com.

Abstract

AP7035a  
LATS1 Antibody (N-term)

Eiring, Anna M., et al. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood 2008 Jan 15;111(2):816-828.

Abstract

AP7088b  
CERK Antibody (C-term)

Hinkovska-Galcheva, Vania, et al. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J. Lipid Res. 2008 Mar 01;49(3):531-542.

Abstract

AP7219b  
DCAMKL1 Antibody (C-term)

May, Randal, et al. Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase-Like-1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple Intestinal Neoplasia Mice. Stem Cells 2008 Mar 01;26(3):630-637.

Abstract

AP7806c  
ACVR1 Antibody (Center R147)

Mitu, Grace M., et al. BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 2007 Nov 01;293(5):F1641-1648.

Abstract

AP8025a  
PI3KR3 Antibody (C-term)

Eiring, Anna M., et al. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood 2008 Jan 15;111(2):816-828.

Abstract

AP8067a  
KIS Antibody (N-term)

Petrovic, Vladimir, et al. FoxM1 Regulates Growth Factor-induced Expression of Kinase-interacting Stathmin (KIS) to Promote Cell Cycle Progression. J. Biol. Chem. 2008 Jan 04;283(1):453-460.

Abstract

AP8111a  
ANPA Antibody (N-term)

Géry Dams, et al. A Time-Resolved Fluorescence Assay to Identify Small-Molecule Inhibitors of HIV-1 Fusion. J Biomol Screen, Sep 2007; 12: 865 - 874. .

Abstract

AP7087b  
DCK Antibody (C-term)

Lamba, Jatinder K., et al. Pharmacogenetics of Deoxycytidine Kinase: Identification and Characterization of Novel Genetic Variants. J. Pharmacol. Exp. Ther. 2007 Dec 01;323(3):935-945.

Abstract

AP1214a  
PRDM14 (PFM11) Antibody (N-term)

Nishikawa, Noriko, et al. Gene Amplification and Overexpression of PRDM14 in Breast Cancers. Cancer Res. 2007 Oct 15;67(20):9649-9657.

Abstract

AP1218c  
LSD1 Antibody (C-term)

Bradley, Chastity, et al. Carcinogen-induced histone alteration in normal human mammary epithelial cells. Carcinogenesis 2007 Oct 01;28(10):2184-2192.

Abstract

AP7028a  
PKC zeta Antibody (N-term)

Lerner-Marmarosh, Nicole, et al. Regulation of TNF-{alpha}-activated PKC-{zeta} signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J 2007 Dec 01;21(14):3949-3962.

Abstract

AP3105a  
Phospho-FGFR-Y766 Antibody

Felicia Ng, et al. PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood, Jul 2008; 112: 295 - 307.

Abstract

AP7039b  
PDK2 Antibody (C-term)

Jeffrey G. Richards, et al. Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus during hypoxia exposure. Am J Physiol Regulatory Integrative Comp Physiol, Sep 2008; 295: R979 - R990.

Abstract

AP1196a  
SET2 Antibody (N-term)

Muller, Waltraud G., et al. Organization of chromatin and histone modifications at a transcription site. J Cell Biol. 2007 Jun 18;177(6):957-67.

Abstract
Full Article

AP1195a  
SET1 Antibody (N-term)

Lee, Jeong-Heon, et al. CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex. J. Biol. Chem. 2005 Dec 16;280(50):41725-41731.

Abstract
Full Article

AP1195b  
SET1 Antibody (C-term)

Lee, Jeong-Heon, et al. CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex. J. Biol. Chem. 2005 Dec 16;280(50):41725-41731.

Abstract
Full Article

AP1222a  
SUMO1 Antibody (C-term)

Rathke, Christina, et al. Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. J. Cell Sci. 2007 May 01;120(9):1689-1700.

Abstract
Full Article

AP1249a  
PIASy1 Antibody (N-term)

Albor, Amador, et al. The Interaction of Piasy with Trim32, an E3-Ubiquitin Ligase Mutated in Limb-girdle Muscular Dystrophy Type 2H, Promotes Piasy Degradation and Regulates UVB-induced Keratinocyte Apoptosis through NF{kappa}B. J. Biol. Chem. 2006 Sep 01;281(35):25850-25866.

Abstract
Full Article

AP2131a  
USP2 Antibody (N-term)

Priolo, Carmen, et al. The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis. Cancer Res. 2006 Sep 01;66(17):8625-8632.

Abstract
Full Article

AP2104b  
SMURF1 Antibody (C-term)

Schwamborn, Jens C., et al. The Interaction of mPar3 with the Ubiquitin Ligase Smurf2 Is Required for the Establishment of Neuronal Polarity. J. Biol. Chem. 2007 Nov 30;282(48):35259-35268.

Abstract
Full Article

AP2105b  
SMURF2 Antibody (C-term)

Schwamborn, Jens C., et al. The Interaction of mPar3 with the Ubiquitin Ligase Smurf2 Is Required for the Establishment of Neuronal Polarity. J. Biol. Chem. 2007 Nov 30;282(48):35259-35268.

Abstract
Full Article

AP2104b  
SMURF1 Antibody (C-term)

Gabriele Sass, et al. TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. J. Immunol., Nov 2007; 179: 7042 - 7049. .

Abstract

AP2105b  
SMURF2 Antibody (C-term)

Gabriele Sass, et al. TNF Pretreatment Interferes with Mitochondrial Apoptosis in the Mouse Liver by A20-Mediated Down-Regulation of Bax. J. Immunol., Nov 2007; 179: 7042 - 7049. .

Abstract

AP3098a  
Phospho-ERK3-S189 Antibody

Purcell, Nicole H., et al. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. PNAS 2007 Aug 28;104(35):14074-14079.

Abstract
Full Article

AP1205a  
PRDM5 (PFM2) Antibody

Watanabe, Yoshiyuki, et al. PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer. Clin. Cancer Res. 2007 Aug 15;13(16):4786-4794.

Abstract
Full Article

AP7933a  
PIM2 Antibody (C-term)

Pogacic, Vanda, et al. Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity. Cancer Res. 2007 Jul 15;67(14):6916-6924.

Abstract
Full Article

AP6807a  
MTMR7 Antibody (C-term)

Yanagiya, Takahiro, et al. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum. Mol. Genet. 2007 Dec 15;16(24):3017-3026.

Abstract
Full Article

AP7041b  
PDK4 Antibody (C-term)

Zaher Nahlé, et al. CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARdelta/beta-mediated Adaptation to Metabolic Stress. J. Biol. Chem., May 2008; 283: 14317 - 14326.

Abstract

AP7540b  
HIPK3 Antibody (C-term)

Lan, Hsin-Chieh, et al. Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expr