| |
Protein phosphorylation regulates crucial processes such as ion
transport, cellular proliferation, and hormone responses. There are
more than 500 serine/threonine, tyrosine, and dual specificity kinases
within the human genome. Cascading phosphorylation of proteins
dynamically controls cell signaling, and disruption of kinase genes
underlies a host of physiological disorders.
Kinase phosphorylation can be reversed by protein phosphatases, and
their synchronization regulates key cellular activities. Most protein
phosphatases are not stringently specific for their substrates.
Consequently, changes in phosphatase activity can broadly impact
turnover of substrates for different kinases, thereby connecting
interrelated signaling pathways. Errors in control of
phosphorylation/dephosphorylation can lead to unchecked cell growth
attributable to human cancers and developmental disease. |
Legend |
Qualification:
DB (Dot Blot)
IF (Immunofluorescence)
IHC (Immunohistochemistry)
IP (Immunoprecipitation)
W (Western Blot)
|
Specificity:
B (Bovine),
C (Chicken), D (Drosphilia), E (C. Elegans), EBV (EBV), G (Neisseria Gonorrhoeae),
H (Human), Ha (Hamster), M (Mouse), P (Pig), Pr (Monkey), R (Rat), Rb (Rabbit),
S (SARS), V (Vaccinia Virus), X (Xenopus), Y (Yeast), Z (Zebrafish)
*Additional species predicted to react based on 93-100% sequence homology. |
|
| Autophagy - Featured Antibodies |
|
| Catalog # |
Target |
Qualification |
Specificity |
| AP8104c NEW |
APG1 (ULK1) (Center) |
W |
H, M |
| AP8104d NEW |
APG1 (ULK1) (Center) |
W |
H |
| AP8104b |
APG1 (ULK1) (C-term ) |
W |
H |
| AP8104a NEW |
APG1 (ULK1) (N-term) |
W |
H |
| AP1815a |
APG10L (N-term) |
IHC |
H |
| AP1151a |
APG12L (N-term) |
IF |
H |
| AP1816a |
APG12L (N-term) |
IHC, W |
H |
| AP1816b |
APG12L (P42) |
IHC |
H |
| AP1816c |
APG12L (P46) |
IHC |
H |
| AP1817a |
APG16L (N-term) |
IHC |
H |
| AP1817b |
APG16L (L176) |
IHC, W |
H, M |
| AP1817c |
APG16L (C-term) |
IHC, W |
H |
| AP1807a |
APG3L (N-term) |
W |
H, B*, M*, R* |
| AP1807b |
APG3L (C-term) |
W |
H, B*, M*, R* |
| AP1807c |
APG3L (C-term K183) |
W |
H, M, B*, R* |
| AP1808a |
APG4A (N-term) |
IHC, W |
H, M |
| AP1808b |
APG4A (Center) |
IHC, W |
H, B* |
| AP1808c |
APG4A (C-term) |
IHC, W |
H, M, B*, R* |
| AP1809a |
APG4B (N-term) |
IHC, W |
H, M |
| AP1809b |
APG4B (G93) |
IHC, W |
H, M, B* |
| AP1809c |
APG4B (C-term) |
IHC, W |
H |
| AP1809d NEW |
APG4B (E273) |
IHC, W |
H |
| AP1810a |
APG4C (N-term) |
IHC, W |
H, M |
| AP1810b |
APG4C (Center) |
IHC, W |
H |
| AP1810c |
APG4C (C-term) |
IHC, W |
H, M |
| AP1811a |
APG4D (N-term) |
IHC, W |
H, M |
| AP1811b |
APG4D (Center) |
IHC, W |
H, M, CM* |
| AP1811c |
APG4D (C-term) |
IHC, W |
H, CM*, P* |
| AP1812a |
APG5L (N-term) |
IHC, W |
H, M, B* C*, R*, P*, Z* |
| AP1812b |
APG5L (C-term) |
IHC, W |
H, M, C*, R* |
| AP1813a |
APG7L (N-term) |
IHC, W |
H, M, R* |
| AP1813b |
APG7L (Center) |
IHC, W |
H, M, C*, R* |
| AP1813c |
APG7L (R509) |
IHC, W |
H, M, R* |
| AP1813d |
APG7L (C-term) |
IHC, W |
H, C*, M*, R* |
| AM1800a |
APG8 (MAP1LC3) |
W |
H, M, R |
| AP1801a |
APG8a (MAP1LC3A) (N-term) |
IHC, W |
H, M, R, B*, C*, Z* |
| AP1801b NEW |
APG8a (MAP1LC3A) (P45) |
IHC, W |
H |
| AP1801c NEW |
APG8a (MAP1LC3A) (I31) |
IHC, W |
H |
| AP1801d NEW |
APG8a (MAP1LC3A) (D106) |
W |
H |
| AP1805a |
APG8a Cleaved (MAP1LC3A) |
IHC, W |
H, M, B*, C*, CM*, R*, Z* |
| AP1803a |
APG8a/b (MAP1LC3A/B) |
IHC |
H, M, R, C*, Z* |
| AP1802a |
APG8b (MAP1LC3B) (N-term) |
IF, IHC, W |
H, M, R, B*, C*, Z* |
| AP1802b |
APG8b (MAP1LC3B) (C-term) |
IHC, W |
H, M, B*, C*, CM* |
| AP1806a |
APG8b Cleaved (MAP1LC3B) |
IF, IHC, W |
H, M, B*, C*, R* |
| AP1804a |
APG8c (MAP1LC3C) (N-term) |
IHC, W |
H, M, R |
| AP1804b |
APG8c (MAP1LC3C) (C-term) |
IHC |
H |
| AP1814a |
APG9L1 (N-term) |
IHC, W |
H |
| AP1814b |
APG9L1 (Center) |
IHC, W |
H |
| AP1814c |
APG9L1 (C-term) |
IHC, W |
H |
| AM1818a NEW |
Beclin 1 (BECN1, APG6) Monoclonal |
W |
H |
| AP1818a |
BECN1 (APG6) (Q196) |
IHC, W |
H, M |
| AP1818b |
BECN1 (APG6) (E225) |
IHC, W |
H, M |
| AP1818c |
BECN1 (APG6) (C-term) |
IHC, W |
H, M |
| AP1821a NEW |
GABARAP (N-term) |
IHC, W |
H |
| AP1851a NEW |
Kinase PI3KC3 (N-term G24) |
IHC, W |
H |
| AP1851b NEW |
Kinase PI3KC3 (C-term E785) |
IHC, W |
H |
| AP1851c NEW |
Kinase PI3KC3 (Center K269 ) |
IHC, W |
H |
| AP1851d NEW |
Kinase PI3KC3 (Center E501) |
IHC, W |
H |
| AP8014a |
Kinase PI3KC3 (N-term ) |
IHC, W |
H |
| AP8014b |
Kinase PI3KC3 (C-term ) |
IHC |
H |
| AP1823a NEW |
LAMP1 (N-term) |
W |
H |
| AP1823b NEW |
LAMP1 (C-term) |
W |
H |
| AP1824b NEW |
LAMP2 (C-term) |
W |
H |
| AP1824c NEW |
LAMP2 (Center) |
W |
H |
| AP1819a |
RAB24 (N-term) |
IHC, W |
H, M |
| AP1819b |
RAB24 (Center) |
IHC, W |
H, M |
| AP1819c |
RAB24 (C-term) |
IHC, W |
H, M |
| AP1820a |
RGS19 (N-term) |
IHC, W |
H |
| AP1820b |
RGS19 (Center) |
IF, IHC, W |
H, M |
| AP1820c |
RGS19 (C-term) |
IHC |
H |
| AP2183b |
SQSTM1 (p62) (C-term ) |
IHC, W |
H |
| AP1850b NEW |
UVRAG (C-term) |
IF, IP |
H, M |
| AP1850c NEW |
UVRAG (Center) |
IHC, W |
H, M |
| AP1850d NEW |
UVRAG (L133) |
IF, IHC, W |
H, M |
| AP1850e NEW |
UVRAG(C-term L555) |
W |
H |
| AS1001a |
Autophagy Pathway Sampler Kit |
|
|
| SP1040a NEW |
Autophagy Inducer: Beclin1 BH3 domain (Cell Permeable, Human, WT) |
|
|
| SP1041a NEW |
Autophagy Inducer: Beclin1 BH3 domain (Human, WT) |
|
|
| SP1043a NEW |
Autophagy Inducer: Beclin1 BH3 domain (Cell Permeable, Zebrafish, WT) |
|
|
| SP1044a NEW |
Autophagy Inducer: Beclin1 BH3 domain (Zebrafish, WT) |
|
|
| SP1046a NEW |
Autophagy Inducer Control: Beclin1 BH3 domain mutant (Cell Permeable, Human, MT1-L116A) |
|
|
| SP1046b NEW |
Autophagy Inducer Control: Beclin1 BH3 domain mutant (Cell Permeable, Human, MT2-F123A) |
|
|
| SP1047a NEW |
Autophagy Inducer Control: Beclin1 BH3 domain mutant (Human, MT1-L116A) |
|
|
| SP1047b NEW |
Autophagy Inducer Control: Beclin1 BH3 domain mutant (Human, MT2-F123A) |
|
|
|
|
