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>   home   >   pathway   >   ³mTOR signaling Pathway

Interactive mTOR Signaling Pathway

erbb-pathwayClick on any interested protein or antibody ID in the mTOR Signaling pathway to list relevant products below.

The mammalian target of rapamycin (mTOR) signaling pathway integrates intracellular and extracellular signals to regulate cell metabolism, growth, proliferation and survival. This pathway is activated during a range of cellular processes (tumor formation, angiogenesis, insulin resistance, adipogenesis, T-lymphocyte activation, etc.) and is dysregulated in diseases such as cancer and diabetes. mTOR inhibitors such as rapamycin and its analogues are used in treatment of solid tumors, organ transplantation, circulatory disease and rheumatoid arthritis.

rapamycin Stress Growth Factors,Hormones,Cytokines, etc. Hypoxia Glucose AMP:ATP AICAR Torin1 PP242 KU63794 WYE354 Autophagy/Lysosome RagulatorComplex Biogenesis mRNA Translation Autophagy Lipid Metabolism Adipogenesis Lipogenesis Transcription VEGF/ Angiogenesis Mitochondrial Metabolism Proliferation Lipid Synthesis Ribosome Biogenesis mRNA Splicing Cell Growth Metformin Amino- Acids PIP 3 PIP 2 mTORC1 mTORC2 SKAR SREBP-1 PRAP PGC-1 HIF-1 PRAP TFEB LAMTOR 1/2/3/4/5 LKB1 RagA/B AMPK RagC/D REDD1/2 GSK-3 RSK Erk Ras PTEN PDK1 PI3K IRS-1 GRB10 Sin1 PRR5 G L mTOR Rictor DEPTOR SGK1 PKC PRAS40 TSC1 Akt TSC2 Rheb Raptor mTOR DEPTOR G L FKBP12 p70S6K Atg1 ULK Atg13 eIF4G 4E- BP1/2 Lipin 1 LRP Frizzled Dvl G Wnt
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