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Catalog #
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Source:
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Lot #
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Size:
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AP1472b
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Rabbit
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SA070904AW
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0.1 mg
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Concentration:
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Accession:
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Clone Name:
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Isotype:
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0.25 mg/ml
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NP_001071, P51649
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RB11949
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Rabbit Ig
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Applications:
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Reactivity:
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MW (kDa):
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WB, E
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H
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57215 Da
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Target/Specificity:
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This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ALDH5A1.
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Other Names:
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NAD(+)-dependent succinic semialdehyde dehydrogenase; Aldehyde dehydrogenase family 5 member A1; SSADH
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Application Data:
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Western blot analysis of ALDH5A1 Antibody (C-term) (Cat.#AP1472b) in SK-BR-3 cell line lysates (35ug/lane). ALDH5A1(arrow) was detected using the purified Pab (1:60 dilution). |
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with *ALDH5A1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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Background:
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ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties.
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Background References:
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- Knerr,I., J. Inherit. Metab. Dis. 30 (3), 279-294 (2007)
- Blasi,P., J. Mol. Evol. 63 (1), 54-68 (2006)
- Plomin,R., Mol. Psychiatry 9 (6), 582-586 (2004)
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Product Citations:
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Application Notes:
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| The suggested dilution is: | |
| ELISA | 1:1,000 |
| Western blotting | 1:50~100 |
| Immunohistochemistry | 1:10~50 |
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Format:
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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Storage:
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
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Precautions:
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This product is for research use only. Not for use in diagnostic
or therapeutic procedures.
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