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Anti-IRE1p (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-IRE1p (C-Terminal) Antibody  ABD10009
    Western blot analysis of whole cell lysate from A-20 mouse B cell lymphoma cells probed with Rabbit anti Human IRE1p at 0.5(A), 1(B) and 2(C) ug/ml
  • ICC - Anti-IRE1p (C-Terminal) Antibody  ABD10009
    Immunocytochemical staining of A-20 cels with rabbit anti Human IRE1p
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75460
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 109735 Da
Additional Information
Other Species Rat,M
Purification Antisera to IRE1p were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen A 16 amino acid peptide near the carboxy terminus of human IRE1p.
Shelf Life 18 months from the date of despatch.
Gene ID 2081
Other Names Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase,, Endoribonuclease, 3.1.26.-, ERN1 (HGNC:3449)
Target/Specificity Rabbit anri IRE1p antibody recognizes the C-terminus of inositol-requiring kinase 1 precursor (IRE1p), a 108 kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-IRE1p (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Zhang, K. and Kaufman, R. (2004) Signaling the Unfolded Protein Response from the Endoplasmic Reticulum.
J. Biol. Chem. 279: 25935-25938.2. Schroder, M. et al. (2003) IRE1-and HAC1 -independent transcriptional regulation in the unfolded protein response of yeast.
Mol. Microbiol. 49: 591-606.3. Tirasophon, W. et al. (1998) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
Genes Dev. 12: 1812-1824.

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Cat# ABD10009
(40 western blots)
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