Anti-Noxa Antibody
Rabbit Anti-Mouse Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P |
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Primary Accession | Q9JM54 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Polyclonal IgG |
Calculated MW | 11566 Da |
Other Species | H,Rat |
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Purification | Antisera to NOXA were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
Immunogen | Synthetic peptide corresponding to N-terminus of mouse NOXA. |
Shelf Life | 18 months from the date of despatch. |
Gene ID | 58801 |
Other Names | Phorbol-12-myristate-13-acetate-induced protein 1, Protein Noxa, Pmaip1, Noxa |
Target/Specificity | Rabbit anti-Murine Noxa antibody recognises murine Noxa, an ~11kDa member of the BH3-only proapoptotic protein family. Noxa is localized to the mitochondria and is a transcriptional target of p73, p53 and BH3-only proteins. It is thought to induce apoptosis when activated, lowering the activity of anti-apoptotic Bcl-2-like proteins. It can be upregulated by mitogenic activation, independently of p53. In humans, along with Mcl-1 it is thought to form a selective pathway that restrains lymphocyte proliferation. |
Preservative & Stabilisers | 0.02% Sodium Azide (NaN3) |
Storage | Store at +4℃ or at -20 ℃. |
Precautions | Anti-Noxa Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |

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Provided below are standard protocols that you may find useful for product applications.
References
1. Oda, E. et al. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053–1058.2. Alves, N. et al. (2006) The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Immunity. 24:703-716.

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