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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human CD283 Antibody    

Anti-Human CD283 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human CD283 Antibody  ABD10012
    Immunocytochemical staining of EL4 mouse lymphoblast cells with Rabbit anti Human CD283
  • WB - Anti-Human CD283 Antibody  ABD10012
    Western blot analysis of whole cell lysate from Daudi human Burkitt's lymphoma derived cells probed with Rabbit anti Human CD283 at 1(A) and 2(B) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15455
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 103829 Da
Additional Information
Other Species M
Purification Antisera to human CD283 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by ion exchange chromatography.
Immunogen Synthetic peptide corresponding to a 15 amino acid sequence located near human CD283 carboxy-terminus.
Shelf Life 18 months from the date of despatch.
Gene ID 7098
Other Names Toll-like receptor 3, CD283, TLR3
Target/Specificity Rabbit anti-Human CD283 antibody recognizes human CD283, otherwise known as toll receptor 3, a 103.8 kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded viral RNA, including that of the Influenza A and West Nile virus.Rabbit anti-Human CD283 antibody has been shown as suitable for use in IHC on EL4 cytospins at 1ug/ml.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD283 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
Nature. 413 (6857): 732-8.2. Guillot, L. et al. (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
J Biol Chem. 280 (7): 5571-80.3. Wang, T. et al. (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.
Nat Med. 10 (12): 1366-73.

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Cat# ABD10012
(40 western blots)
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