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Anti-Human XEDAR Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human XEDAR Antibody  ABD10015
    Immunohistochemical staining of human skin with Rabbit anti Human XEDAR
  • WB - Anti-Human XEDAR Antibody  ABD10015
    Western blot analysis of whole cell lysates from HEH293 human epithelial kidney cells probed with Rabbit anti Human XEDAR at 0.5(A), 1(B) and 2(C)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HAV5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 32759 Da
Additional Information
Purification Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human XEDAR.
Shelf Life 18 months from the date of despatch.
Gene ID 60401
Other Names Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, TNFRSF27, XEDAR
Target/Specificity ABD10015 detects human X-linked ectodermal dysplasia receptor (XEDAR), a 33kD type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. New evidence suggests XEDAR may also be involved in skeletal muscle development.Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human XEDAR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Sinha, S.K. et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
J. Biol. Chem. 277: 44953-449612. Sinha, S.K. and Chaudhary, P.M. (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
J. Biol. Chem. 279: 41873-41881.3. Newton, K. et al. (2004) Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.
Mol. Cell. Biol. 24: 1608-1613.

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Cat# ABD10015
(40 western blots)
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