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Anti-TDP43 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-TDP43 Antibody  ABD10021
    Immunocytochemical staining of HeLa cells with Rabbit anti Human TPD43
  • WB - Anti-TDP43 Antibody  ABD10021
    Western blot analysis of whole cell lysates from L1210 B-cell like lymphocytic leukemia cells probed with Rabbit anti TPD43 at 0.5(A) and 21(B) ug/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13148
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 44740 Da
Additional Information
Other Species Rat,M
Purification Purified IgG was prepared by affinity chromatography.
Immunogen An 18 amino acid peptide located near the centre of human TDP43.
Shelf Life 18 months from the date of despatch.
Gene ID 23435
Other Names TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
Target/Specificity ABD10021 recognises TAR DNA-binding protein 43 (TDP43), a 43 kDa protein that is located in the nucleus. TDP43 is ubiquitously expressed in human tissue, with high levels detected in the lung, pancreas, spleen, placenta and genital tract. ABD10021 recognises the longer of the two TDP43 isoforms identified. TDP43 is transcriptional repressor protein that binds to chromosomally integrated TAR DNA and represses HIV-1 Transcription. Studies also suggest that TDP43 is involved in the regulation of cystic fibrosis transmembrane conductance regulator (CFTR) splicing, probably through the association with UG repeats at the 3’ splice site. A pathologic form of TDP43 has also been identified, which is a major disease protein in ubiquitinated inclusions characteristic of a range of neurodegenerative diseases.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-TDP43 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Ou, S.H. et al. (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
J Virol. 69:3584 – 3596.

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Cat# ABD10021
(40 western blots)
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