|Application ||WB, IHC-F|
|Calculated MW||44740 Da|
|Purification||Purified IgG was prepared by affinity chromatography.|
|Immunogen||An 18 amino acid peptide located near the centre of human TDP43.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43|
|Target/Specificity||ABD10021 recognises TAR DNA-binding protein 43 (TDP43), a 43 kDa protein that is located in the nucleus. TDP43 is ubiquitously expressed in human tissue, with high levels detected in the lung, pancreas, spleen, placenta and genital tract. ABD10021 recognises the longer of the two TDP43 isoforms identified. TDP43 is transcriptional repressor protein that binds to chromosomally integrated TAR DNA and represses HIV-1 Transcription. Studies also suggest that TDP43 is involved in the regulation of cystic fibrosis transmembrane conductance regulator (CFTR) splicing, probably through the association with UG repeats at the 3’ splice site. A pathologic form of TDP43 has also been identified, which is a major disease protein in ubiquitinated inclusions characteristic of a range of neurodegenerative diseases.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-TDP43 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ou, S.H. et al. (1995) Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol. 69:3584 – 3596.
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