|Application ||WB, IHC-F|
|Calculated MW||83642 Da|
|Purification||Antiserum to human NAK was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A peptide corresponding to 17 amino acids near the carboxy terminus of human NAK.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Serine/threonine-protein kinase TBK1, 22.214.171.124, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, TBK1, NAK|
|Target/Specificity||Rabbit anti-NAK (C-Terminal) antibody recognizes human NF-kB-activating kinase (NAK), otherwise known as TANK-binding kinase 1 (TBK1). It is involved in the signalling cascade of NF-kB activation by directly phosphorylating and activating IKK Beta. It also mediates the production of IFN Beta and CCL5 and plays a key role in the innate immune response. In addition, it phosphorylates and activates the interferon regulatory factors -3 and -7, eventually leading to the development of a cellular antiviral state. It may also be involved in the induction of the antiviral interferon response. NAK is expressed ubiquitously, with higher expression in testis.Rabbit anti-NAK (C-Terminal) antibody does not cross-react with IKK Alpha, IKK Beta, IKK Gamma or IKK Epsilon.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-NAK (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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