|Application ||WB, IHC-F|
|Calculated MW||51530 Da|
|Purification||Antiserum to IRAK4 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by chromatography.|
|Immunogen||A peptide corresponding to amino acids at the carboxy terminus of human IRAK4.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Interleukin-1 receptor-associated kinase 4, IRAK-4, 188.8.131.52, Renal carcinoma antigen NY-REN-64, IRAK4|
|Target/Specificity||Rabbit anti-Human IRAK4 (C-Terminal) antibody detects an epitope within the C-Terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 has a molecular weight of 50kD, and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization.IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human IRAK4 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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