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Anti-Human IRAK4 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • ICC - Anti-Human IRAK4 (C-Terminal) Antibody  ABD10028
    Immunocytochemical staining of K562 human erythromyeloblastoid cell line with Rabbit anti Human IRAK4
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NWZ3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 51530 Da
Additional Information
Purification Antiserum to IRAK4 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by chromatography.
Immunogen A peptide corresponding to amino acids at the carboxy terminus of human IRAK4.
Shelf Life 18 months from the date of despatch.
Gene ID 51135
Other Names Interleukin-1 receptor-associated kinase 4, IRAK-4,, Renal carcinoma antigen NY-REN-64, IRAK4
Target/Specificity Rabbit anti-Human IRAK4 (C-Terminal) antibody detects an epitope within the C-Terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 has a molecular weight of 50kD, and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization.IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human IRAK4 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Suzuki, N. et al. (2002) IRAK-4 as the central TIR signaling mediator in innate immunity.
Trends Immunol. 10: 503-506.2. Suzuki, N. and Saito, T. (2006) IRAK-4- a shared NF-kappaB activator in innate and acquired immunity.
Trends Immunol. 27: 566-572.

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Cat# ABD10028
(40 western blots)
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