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Anti-RIG-I Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-RIG-I Antibody  ABD10032
    Western blot analysis of whole cell lysate from C2C12 mouse myoblast cells probed with Rabbit anti Human RIG-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC - Anti-RIG-I Antibody  ABD10032
    Immunohistochemical staining of human heart with Rabbit anti Human RIG-1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95786
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 106600 Da
Additional Information
Other Species M,Rat
Purification Antisera to human RIG-I were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Immunogen Human GST-tagged RIG-1 protein.
Shelf Life 18 months from the date of despatch.
Gene ID 23586
Other Names Probable ATP-dependent RNA helicase DDX58,, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, DDX58
Target/Specificity Rabbit anti-RIG-I antibody recognizes human Retinoic acid-inducible gene 1 protein (RIG-I), also known as RIG-1 or DEAD-box protein 58. RIG-I is a receptor found in the cytoplasm that recognizes viral RNA from replicating viruses in infected cells. Upon activation with intracellular RNA, a cascade is triggered resulting in the activation of NF-kappa-B, and the eventual induction of antiviral cytokines such as IFN-beta and RANTES. RIG-I is essential for the production of interferons in response to RNA viruses and as such play a key role in innate immunity.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-RIG-I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Satoh, T. et al. (2014) Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
J Clin Exp Hematop. 54: 75-84.1. Akira S, et al (2006) Pathogen recognition and innate immunity
124:783-8012. Yoneyama M et al (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nat. Immunol.; 5:730-737.3. Sharma S, et al (2003) Triggering the interferon antiviral response through an IKK-related pathway
Science 300:1148-51.4. Alexopoulou L, et al (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
Nature 413:732-8

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$ 275.00
$ 144.00
Cat# ABD10032
1 Formats Available
Availability: 5-7days
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