|Calculated MW||76613 Da|
|Purification||Antisera to human LGP2 (N-Terminal) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||Peptide corresponding to a 14 amino acid sequence from near the amino terminus of human LGP2.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Probable ATP-dependent RNA helicase DHX58, 188.8.131.52, Probable ATP-dependent helicase LGP2, Protein D11Lgp2 homolog, RIG-I-like receptor 3, RLR-3, RIG-I-like receptor LGP2, RLR, DHX58, D11LGP2E, LGP2|
|Target/Specificity||Rabbit anti-LGP2 (N-Terminal) antibody recognizes human Probable ATP-dependent helicase LGP2 (LGP2), also known as DHX58, a 768aa cytoplasmic protein belonging to the Helicase family.LGP2 is a negative regulator of host innate immune defense against viruses. The repressor domain of LGP2 interacts with RIG-I and negatively regulates RIG-I mediated signaling. LGP2 binds to dsRNA produced during viral replication, in particuliar HCV RNA.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-LGP2 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Akira S, et al (2006) Pathogen recognition and innate immunityCell; 124:783-8012. Iwasaki A et al (2004) Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5:987-95.3. Yoneyama M, et al (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5:730-7. Nat. Immunol. 5:730-737
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