|Application ||WB, IHC-P, E|
|Calculated MW||46343 Da|
|Purification||Antisera to human DAI were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.|
|Immunogen||Synthetic peptide corresponding to an 18 amino acid sequence from near the carboxy terminus of human ZBP1.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Z-DNA-binding protein 1, Tumor stroma and activated macrophage protein DLM-1, ZBP1, C20orf183, DLM1|
|Target/Specificity||This product recognizes human DAI, also known as Z-DNA Binding Protein (ZBP1), a 46kDa DNA binding protein belonging to a family of proteins that contain a Za domain which specifically binds to the left-handed Z-DNA and Z-RNA. Initial studies suggested that DAI may be involved in processes such host response to neoplasia. Additional research has indicated that the cytosolic DAI can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of DAI to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). DAI is highly expressed in lymphatic tissues such as lymph nodes, leukocytes, tonsil, bone marrow and spleen. Expression at a lower level is also seen in thymus, lung and liver. It has been demonstrated that multiple isoforms of DAI exist.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-DAI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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