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Anti-DAI Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-DAI Antibody  ABD10034
    Formalin fixed, paraffin embedded human small intestine stained with Rabbit anti Human DAI following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
  • WB - Anti-DAI Antibody  ABD10034
    Western blot analysis of mouse small intestine lysate probed with Rabbit anti Human DAI at 0.5(A), 1(B) and 2(C)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H171
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 46343 Da
Additional Information
Other Species M,Rat
Purification Antisera to human DAI were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Immunogen Synthetic peptide corresponding to an 18 amino acid sequence from near the carboxy terminus of human ZBP1.
Shelf Life 18 months from the date of despatch.
Gene ID 81030
Other Names Z-DNA-binding protein 1, Tumor stroma and activated macrophage protein DLM-1, ZBP1, C20orf183, DLM1
Target/Specificity This product recognizes human DAI, also known as Z-DNA Binding Protein (ZBP1), a 46kDa DNA binding protein belonging to a family of proteins that contain a Za domain which specifically binds to the left-handed Z-DNA and Z-RNA. Initial studies suggested that DAI may be involved in processes such host response to neoplasia. Additional research has indicated that the cytosolic DAI can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of DAI to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). DAI is highly expressed in lymphatic tissues such as lymph nodes, leukocytes, tonsil, bone marrow and spleen. Expression at a lower level is also seen in thymus, lung and liver. It has been demonstrated that multiple isoforms of DAI exist.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-DAI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Takaoda A et al (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature 448:501-5. 2. Schwartz T, et al. (2001) Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Nat. Struct. Biol. 8:761-5

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Cat# ABD10034
(40 western blots)
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