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Anti-Caspase-7 (N-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Caspase-7 (N-Terminal) Antibody  ABD10038
    Western blot analysis of mouse skeletal muscle lysate probed with Rabbit anti Human caspase-7 at 0.5(A) and 1(B) ug/ml
  • IHC-P - Anti-Caspase-7 (N-Terminal) Antibody  ABD10038
    Formalin fixed, paraffin embedded rat skeletal muscle stained with Rabbit anti Human caspase-7 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P97864
Other Accession P55210
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 34061 Da
Additional Information
Other Species M,Rat
Purification Antiserum to human Caspase-7 (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen A 16 amino acid peptide from human Caspase-7 amino-terminus.
Shelf Life 18 months from the date of despatch.
Gene ID 12369
Other Names Caspase-7, CASP-7,, Apoptotic protease Mch-3, Cysteine protease LICE2, Caspase-7 subunit p20, Caspase-7 subunit p11, Caspase-7, N-terminally processed, Casp7, Lice2, Mch3
Target/Specificity Rabbit anti-Caspase-7 (N-Terminal) antibody recognizes an epitope within the N-Terminal region (NT) of Caspase-7, a 35kDa cysteine protease, otherwise known as ICE-like Apoptotic Protease 3 (ICE-LAP3).Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumour necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B mediated apoptosis pathways.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Caspase-7 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Duan, H. et al. (1996) ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
J. Biol Chem. 271: 1621 - 1625.2. Juan, T.S. et al. (1997) Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.
Genomics. 40: 86-93.3. Cohen, G.M. (1997) Caspases: the executioners of apoptosis.
J. Biochem. 326: 1 - 16.

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Cat# ABD10038
(40 western blots)
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