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Anti-Human FLIP L (C-Terminal) Antibody
Rabbit Anti-Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F |
|---|---|
| Primary Accession | O15519 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 55344 Da |
| Purification | Antisera to FLIP were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography. |
|---|---|
| Immunogen | Peptide at C-terminus of human FLIPL |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 8837 |
| Other Names | CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, CFLAR, CASH, CASP8AP1, CLARP, MRIT |
| Target/Specificity | ABD10046 recognises the 55kD FLIPL protein, a FLICE inhibitory protein.FLIP was cloned independently in a number of laboratories, and is also known as Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP has two death effector domains (DEDs) and a caspase-like domain. It interacts with FADD and caspase-8 and -10, potently inhibiting apoptosis by all known death receptors.FLIP exists in a short form (FLIPS) and a long form (FLIPL). Only FLIPL is recognised by this antibody. |
| Preservative & Stabilisers | 0.02% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human FLIP L (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Irmler, M. et al. (1997) Inhibition of death receptor signals by cellular FLIP.Nature 388: 190-195.
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Cat# ABD10046
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