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Anti-Human BAX Antibody (Serum)

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07812
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 21184 Da
Additional Information
Purification Antisera to human BAX was raised by repeated immunisation of rabbits with highly purified antigen.
Immunogen Synthetic peptide, CPELALDPVPQDASTKKLSE, corresponding to amino acids 43-61 of human BAX.
Shelf Life 18 months from date of despatch.
Gene ID 581
Other Names Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4
Target/Specificity Rabbit anti-Human BAX antibody recognizes the human BAX protein, a proapoptotic member of the Bcl-2 family. BAX accelerates programmed cell death by binding to and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. It also induces the release of cytochrome C , activation of CASP3 and thereby apoptosis. Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.BAX migrates as a 21kD band in western blotting applications.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human BAX Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Krajewski, S. et al. (1995) Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.
Cancer Res. 55: 4471-4478. 2. Condon, L.T. et al. (2002) Overexpression of Bcl-2 in squamous cell carcinoma of the larynx: a marker ofradioresistance.
Int J Cancer. 100: 472-5. 3. Gonzalez-Campora, R. et al. (2007) BCL-2, TP53 and BAX protein expression in superficial urothelial bladder carcinoma.
Cancer Lett. 250: 292-9. 4. Siu, W.P. et al. (2008) Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A.
Toxicol Appl Pharmacol. 227: 451-61. 5. Leong, A.S. et al. (2008) Apoptosis is a major cause of so-called"caseous necrosis"in mycobacterial granulomas in HIV-infected patients.
J Clin Pathol. 61: 366-72. 6. Wang, C.Y. et al. (2009) Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis.
Mol Biol Cell. 20: 4153-61. 7. Feinmesser, M. et al. (2003) Differential expression of proliferation- and apoptosis-related markers in lentigo maligna and solar keratosis keratinocytes.
Am J Dermatopathol. 25: 300-7.

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Cat# ABD10049
(40 western blots)
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