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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Anti-APAF1 (aa12-28) Antibody    

Anti-APAF1 (aa12-28) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-APAF1 (aa12-28) Antibody  ABD10052
    Immunohistochemical staining of human heart with Rabbit anti APAF1
  • WB - Anti-APAF1 (aa12-28) Antibody  ABD10052
    Western Blot analysis of whole cell lysate from K562 cells probed with Rabbit anti APAF1 either in the absence (A) or presence (B) of blocking peptide
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14727
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 141840 Da
Additional Information
Other Species M
Purification Antisera to human Apaf-1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Synthetic peptide corresponding to amino acids 12-28 of human Apaf1
Shelf Life 18 months from date of despatch.
Gene ID 317
Other Names Apoptotic protease-activating factor 1, APAF-1, APAF1, KIAA0413
Target/Specificity Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C. Elegans. Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, resulting in the beginning of the proteolytic cascade characteristic of apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. ABD10052 recognises a 130kD band in Western blots.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-APAF1 (aa12-28) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Zou, H. et al. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.
Cell 90: 405-413.2. Cecconi, F. et al. (1998) Apaf-1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Cell 94: 727-737.3. Hu, Y. et al. (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1 dependent caspase-9 activation.
Proc. Natl. Acad. Sci. USA. 95: 4386-4391.

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Cat# ABD10052
(40 western blots)
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