|Application ||WB, IHC-P, E|
|Calculated MW||27661 Da|
|Purification||Antisera to human PrP27-30 were raised by repeated immunisation of goats with highly purified antigen.|
|Immunogen||Synthetic peptide corresponding to amino acids 79-97 of the N-terminus of human prion protein|
|Shelf Life||18 months from date of despatch.|
|Other Names||Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, CD230, PRNP, ALTPRP, PRIP, PRP|
|Target/Specificity||Goat anti-Human CD230 antibody recognizes human Major prion protein, also known as PrP27-30, CD230, or PrP33-35C. CD230 is a 253 amino acid ~27 kDa GPI anchored membrane protein. CD230 is found in large amounts in the brain of patients with transmissible spongiform encephalopathies (TSEs) or prion diseases, fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.Goat anti-Human CD230 (N-Terminal) antibody has been shown to stain PrPScplaques in formalin fixed sections of CJD brain. It also reacts with PrPc.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD230 (N-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Shinagawa, M. et al. (1986) Immunoreactivity of a synthetic pentadecapeptide corresponding to the N-terminal region of the scrapie prion protein.J Gen Virol. 67 ( Pt 8): 1745-50. 2. Mao-Draayer, Y.et al. (2002) Emerging patterns of diffusion-weighted MR imaging in Creutzfeldt-Jakob disease: case report and review of the literature.AJNR Am J Neuroradiol. 23 (4): 550-6.
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