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Anti-Human CD230 (N-Terminal) Antibody (Serum)

Goat Anti-Human Polyclonal Antibody

  • IHC-P - Anti-Human CD230 (N-Terminal) Antibody (Serum) ABD10055
    Creutzfeldt-Jakob Disease brain showing immunohistochemical staining of prion plaque with AHP498T at 1:200 dilution in formalin-fixed, paraffin-embedded section of cerebral cortex
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04156
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 27661 Da
Additional Information
Other Species B,Sh,Ha
Purification Antisera to human PrP27-30 were raised by repeated immunisation of goats with highly purified antigen.
Immunogen Synthetic peptide corresponding to amino acids 79-97 of the N-terminus of human prion protein
Shelf Life 18 months from date of despatch.
Gene ID 5621
Other Names Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, CD230, PRNP, ALTPRP, PRIP, PRP
Target/Specificity Goat anti-Human CD230 antibody recognizes human Major prion protein, also known as PrP27-30, CD230, or PrP33-35C. CD230 is a 253 amino acid ~27 kDa GPI anchored membrane protein. CD230 is found in large amounts in the brain of patients with transmissible spongiform encephalopathies (TSEs) or prion diseases, fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.Goat anti-Human CD230 (N-Terminal) antibody has been shown to stain PrPScplaques in formalin fixed sections of CJD brain. It also reacts with PrPc.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD230 (N-Terminal) Antibody (Serum) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Shinagawa, M. et al. (1986) Immunoreactivity of a synthetic pentadecapeptide corresponding to the N-terminal region of the scrapie prion protein.
J Gen Virol. 67 ( Pt 8): 1745-50. 2. Mao-Draayer, al. (2002) Emerging patterns of diffusion-weighted MR imaging in Creutzfeldt-Jakob disease: case report and review of the literature.
AJNR Am J Neuroradiol. 23 (4): 550-6.

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Cat# ABD10055
(40 western blots)
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