|Application ||WB, IHC-P|
|Calculated MW||66901 Da|
|Purification||Antisera to AIF were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.|
|Immunogen||Peptide corresponding to amino acids 517 - 531 of human AIF.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Apoptosis-inducing factor 1, mitochondrial, 1.1.1.-, Programmed cell death protein 8, AIFM1, AIF, PDCD8|
|Target/Specificity||Rabbit anti-Human AIF antibody recognizes human Apoptosis-inducing factor 1, mitochondrial, also known as Programmed cell death protein 8 or apoptosis inducing factor (AIF). AIF is a 613 amino acid member of the FAD-dependent oxidoreductase family.Rabbit anti-Human AIF antibody reacts with an internal region of AIF (within the region aa 517-531. AIF is widely expressed in human tissues and localizes in the mitochondria. AIF translocates to the nucleus upon induction of apoptosis. Multiple isoforms of AIF are generated by alternative splicing. Rabbit anti-Human AIF antibody recognizes isoforms 1, 2,3 and 5. It is not expected to recognize either isoforms 4 or 6 as they lack the immunogen sequence.Mutations in the AIFM1 can result in various disease conditions including COXPD6andCowchock syndrome.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-AIF (aa517-531) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Susin. S.A. et al. (1999) Molecular characterization of mitochondrial apoptosis - inducing factor.Nature. 397: 441-6.
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