|Application ||WB, IHC-P, IHC-F, IF, E|
|Calculated MW||60292 Da|
|Other Species||M,H,Fish,Atlantic Stingray|
|Purification||Antisera to calcitonin receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein A.|
|Immunogen||Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Calcitonin receptor, CT-R, C1A/C1B, Calcr|
|Target/Specificity||Rabbit anti-Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. Rabbit anti-Rat Calcitonin Receptor antibody recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b rat isoforms.Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Calcitonin Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Wookey, P. J. et al. (2008) Calcitonin receptor immunoreactivity associated with specific cell types in diseased radial and internal mammary arteries.Histopathology 52: 605-612. 2. Tolcos, M. et al. (2003) Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat. J. Comp. Neurol. 456: 29 - 38. 3. Tikellis, C. et al. (2003) Calcitonin receptor isoforms expressed in the developing rat kidney.Kidney Int. 63: 416-26. 4. Gnocchi, V.F. et al. (2009) Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells.PLoS One. 4(4):e5205. 5. Becskei, C. et al. (2004) Immunohistochemical mapping of calcitonin receptors in the adult rat brain.Brain Res. 1030: 221-33. 6. Gooi, J.H. et al. (2010) Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes.Bone. 46: 1486-97. 7. Gelsleichter, J.J. (2006) MCAA: Development of laboratory skills in molecular biology to examine patterns of calcitonin and calcitonin receptor gene expression in cartilaginous fishes.Mote technical report 1392. 8. Wookey, P.J. et al. (2012) Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse.Cell Tissue Res. 347: 311-7. 9. Mourikis, P. et al. (2012) Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells.Development. 139: 4536-48. 10. Park, J.K. et al. (2012) Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.PLoS One. 7: e42659. 11. Le Roux, I. et al. (2015) Numb is required to prevent p53-dependent senescence following skeletal muscle injury.Nat Commun. 6: 8528. 12. Almeida, C. et al. (2016) Muscle satellite cells: exploring the basic biology to rule themStem Cells Int. 24 Jan [Epub ahead of print] 13. Yamaguchi, M. et al. (2015) Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.Cell Rep. 13 (2): 302-14. 14. Wookey, P.J. (2009) A Review of Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues, with an Hypothesis on the Connection Between Expression During Foetal Development and DiseaseThe Open Zoology Journal 2: 53-61.
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