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Rabbit Anti-Human Polyclonal Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P55210 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 34277 Da |
| Other Species | M,Rat |
|---|---|
| Purification | Antisera to human Caspase-7 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
| Immunogen | A 16 amino acid peptide from human Caspase-7 carboxy-terminus |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 840 |
| Other Names | Caspase-7, CASP-7, 3.4.22.60, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11, CASP7, MCH3 |
| Target/Specificity | ABD10079 recognises an epitope within the C-terminal region (CT) of Caspase-7, a 35kDa cysteine protease, otherwise known as ICE-like Apoptotic Protease 3 (ICE-LAP3). Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumour necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B mediated apoptosis pathways. |
| Preservative & Stabilisers | 0.02% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Caspase-7 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Duan, H. et al. (1996) ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.J. Biol Chem. 271: 1621 - 1625.2. Juan, T.S. et al. (1997) Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.Genomics. 40: 86-93.3. Cohen, G.M. (1997) Caspases: the executioners of apoptosis.J. Biochem. 326: 1 - 16.
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