|Calculated MW||55686 Da|
|Purification||Antisera to human Akt1 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||A 16 amino acid peptide located near the human Akt1 amino-terminus.|
|Shelf Life||18 months from date of despatch.|
|Other Names||RAC-alpha serine/threonine-protein kinase, 220.127.116.11, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC|
|Target/Specificity||Rabbit anti-AKT1 antibody recognizes the N-terminal region of Akt1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt. AKT1 is a 480 amino acid ~48 kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN (Cantley et al.1999). Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression (Sun et al.2001).|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-AKT1 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Stern, D.F. (2004) More than a marker... Phosphorylated Akt in prostate carcinoma.Clin Cancer Res. 10: 6407-10.
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