|Calculated MW||20497 Da|
|Purification||Antisera to human Rheb (IN) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||A 15 amino acid peptide located in the internal region of human Rheb.|
|Shelf Life||18 months from date of despatch.|
|Other Names||GTP-binding protein Rheb, Ras homolog enriched in brain, RHEB, RHEB2|
|Target/Specificity||ABD10081 recognises Ras homologue enriched in brain (Rheb) a 17kDa G-protein and evolutionarily conserved Ras family member, widely expressed in tissues other than the brain.Compared with many small GTPases, Rheb is unique since it exists in a highly activated state in mammalian cells. Rheb also plays an important part in regulating the TOR signally pathway.Although Rheb is expressed at relatively high levels in the adult cortex, it can be rapidly induced in brain neurons by synaptic activity. Following a seizure, it is transiently induced in the hippocampus.|
|Preservative & Stabilisers||0.02% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-RHEB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Zhang, Y. et al. (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.Nature Cell Biology. 5: 578-581.2. Yamagata, K. et al. (1994) Rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.J. Biol. Chem. 269: 16333-16339.
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