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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-AID (C-Terminal) Antibody    

Anti-AID (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-AID (C-Terminal) Antibody  ABD10082
    Western blot analysis of whole cel lysate from Ramos human Burkitt lymphomma cell line probed with Rabbit anti Human AID in the absence (A) or presence (B) of blocking peptide
  • ICC - Anti-AID (C-Terminal) Antibody  ABD10082
    Immunocytochemical staining of Ramos cells with Rabbit anti Human AID
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9GZX7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 23954 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography.
Immunogen A 14 amino acid peptide located near human AID carboxy-terminus.
Shelf Life 18 months from date of despatch.
Gene ID 57379
Other Names Single-stranded DNA cytosine deaminase,, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA, AID
Target/Specificity ABD10082 recognises an epitope within the C-terminal region (CT) of Activation-induced cytidine deaminase (AID), a 24kDa homologue of the RNA-editing cytidine deaminase enzyme, APOBEC-1. Although the molecular mechanisms by which AID acts remain unclear, a growing number of studies reveal a requirement for AID during somatic hypermutation (SHM) and class switch recombination (CSR). These genetic modification events take place within highly specialised B cell germinal centres, during the final maturation stages of B cells, giving rise to high-affinity antibodies which use CSR to switch from IgM to IgG, IgA or IgE isotypes.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-AID (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Muramatsu, M. et al. (1999) Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells*.
J. Biol. Chem. 274: 18470-18476.2. Muramatsu, M. et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Cell. 102: 553-563.3. Yu, K. et al. (2005) Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops.
Mol. and Cell. Biol. 25: 1730-1736

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Cat# ABD10082
(40 western blots)
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