|Application ||IHC-P, IHC-F, IF|
|Calculated MW||9806 Da|
|Immunogen||A peptide CATQRLANFLV corresponding to residues 40-50 of human IAPP coupled to tuberculin|
|Shelf Life||18 months from date of despatch.|
|Other Names||Islet amyloid polypeptide, Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide, IAPP|
|Target/Specificity||Mouse anti-Human Amylin antibody, clone R10/99 recognizes the islet amyloid polypeptide (amylin). Mouse anti-Human Amylin antibody, clone R10/99 is of high affinity, and stains islet amyloid peptide in intra-cellular insulin granules, intra-cellular amyloid and extra-cellular islet amyloid.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Amylin Antibody, clone R10/99 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Gong, W. (2007) Amylin deposition in the kidney of patients with diabetic nephropathy.Kidney Int. 72: 213-218. 2. Bhattacharya, S. et al. (2007) Cloning and expression of human islet amyloid polypeptide in cultured cells.Biochem Biophys Res Commun. 356: 622-8. 3. Gurlo, T. et al. (2010) Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.Am J Pathol. 176: 861-9. 4. Zhao, H. et al. (2010) Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition.Pancreas. 39: 843-6. 5. Nakamura, S. et al. (2008) Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey.Vet Pathol. 45: 67-72. 6. Zhao, H.L. et al. (2009) Amyloid oligomers in diabetic and nondiabetic human pancreas.Transl Res. 153: 24-32. 7. Campbell-Thompson, M.L. et al. (2012) Staining protocols for human pancreatic islets.J Vis Exp. 63: e4068.
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