|Application ||WB, IF, FC, IP|
|Calculated MW||30654 Da|
|Purification||Purified IgG prepared by ion exchange chromatography|
|Immunogen||ICAM-2 transfected CHO cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Intercellular adhesion molecule 2, ICAM-2, CD102, ICAM2|
|Target/Specificity||Mouse anti-Human CD102 antibody, clone B-T1 recognizes human Intercellular adhesion molecule 2, also known as CD102 or ICAM-2. CD102 is a 275 amino acid ~55-65 kDa single pass type-1 transmembrane glycoprotein containing two Ig-like C2-typedomains.Mouse anti-Human CD102 antibody, clone B-T1 inhibits cell adhesion (Xieet al.1995)and T cell activation and also recognises soluble ICAM-2.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD102 Antibody, clone B-T1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Xie, J. et al. (1995) Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain.J Immunol. 155 (7): 3619-28. 2. Jolly, C. et al. (2007) Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.J Virol. 81 (24): 13916-21. 3. Huang, M.T. et al. (2005) Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis.Blood. 106:1636-43. 4. Birdsey, G.M. et al. (2008) Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.Blood. 111: 3498-506. 5. Carreno, M.P. et al. (2002) Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.J Virol. 76: 32-40. 6. Starke, R.D. et al. (2011) Endothelial von Willebrand factor regulates angiogenesis.Blood. 117: 1071-80. 7. Ishido, S. et al. (2000) Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.Immunity. 13: 365-74. 8. Fricke. B. et al. (2005) Stomatin is mis-trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes.Br J Haematol.131: 265-77. 9. Garbe, Y. et al. (2011) Semiallogenic fusions of MSI(+) tumor cells and activated B cells induce MSI-specific T cell responses.BMC Cancer. 11: 410. 10. McLaughlin, F. et al. (1998) Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta down-regulate intercellular adhesion molecule (ICAM)-2 expression on the endothelium.Cell Adhes Commun. 6 (5): 381-400.
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