|Application ||IHC-F, FC|
|Other Accession||P40199, P13688|
|Calculated MW||27091 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d, CEACAM3, CD66D, CGM1|
|Target/Specificity||Rat anti-Human CD66acd antibody, clone YTH71.3 recognizes 3 members of the human CD66 family, namely CD66a, also known as Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1 or CEACAM1. Clone YTH71.3 also recognizes CD66c, known as Carcinoembryonic antigen-related cell adhesion molecule 6 or Non-specific crossreacting antigen. In addition the clone also recognizes CD66d which in turn is also known as Carcinoembryonic antigen-related cell adhesion molecule 3 or CGM1 (Wattet al.1991). CD66 family members are single pass, type 1 membrane glycoproteins bearing a single V-type Ig-like domain and a varying number of C2-type Ig-like domains. Clone YTH71.3 recognizes epitopes in the N-terminal domain of these CD66 family members.CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma (Neumaier|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD66acd Antibody, clone YTH71.3 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Watt, S.M. et al. (1991) CD66 identifies a neutrophil-specific epitope within the haematopoietic system that is expressed by members of the carcinoembryonic family of adhesion molecules.Blood 78: 63-74. 2. Skubitz, K.M. et al. (1993) In Leucocyte Typing V. White Cell Differentiation Antigen p. 889 - 899 Volume One.Oxford University Press, Oxford. 3. Jonker, M. et al. (1989) Reactivity of Mab specific for human CD markers with Rhesus monkey leucocytes.Leucocyte Typing IV p 1058-1063 Oxford University Press, Oxford. 4. N'Guessan, P.D. et al. (2007) The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells.J Infect Dis. 195: 1651-60. 5. Hill, D.J. and Virji, M. (2003) A novel cell-binding mechanism of Moraxella catarrhalis ubiquitous surface protein UspA: specific targeting of the N-domain of carcinoembryonic antigen-related cell adhesion molecules by UspA1.Mol Microbiol. 48: 117-29. 6. Bradley, C.J. et al. (2005) Critical determinants of the interactions of capsule-expressing Neisseria meningitidis with host cells: the role of receptor density in increased cellular targeting via the outer membrane Opa proteinsCell Microbiol. 7: 1490-503.
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