|Application ||WB, IHC-P, IHC-F, IF, E|
|Calculated MW||309265 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||Factor VIII complex|
|Shelf Life||18 months from date of despatch.|
|Other Names||von Willebrand factor, vWF, von Willebrand antigen 2, von Willebrand antigen II, VWF, F8VWF|
|Target/Specificity||Mouse anti-Human von Willebrand Factor antibody, clone 21-43 reacts with human von Willebrand's factor (also known as Factor VIII related antigen) in both plasma and tissues. Mouse anti-Human von Willebrand Factor antibody, clone 21-43 does not have anti-coagulant activity.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human von Willebrand Factor Antibody, clone 21-43 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Francis, S.E. et al. (1985) Monoclonal antibodies to human FVIII: Ag and FVIIIC Pathology 17: 579-585. 3. Babich, V. et al. (2009) Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body.J Biol Chem. 284: 12459-68. 3. Francis, S. et al. (1984) Some studies with monoclonal antibodies to Human Factor VIII.Proceedings of the Haematology Society of Australia, Perth. 4. Blagoveshchenskaya, A.D. et al. (2002) Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor.Mol Biol Cell. 13: 1582-93. 5. Henke, P.K. et al. (2011) Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution.Arterioscler Thromb Vasc Biol. 31: 43-9. 6. Knipe, L. et al. (2010) A revised model for the secretion of tPA and cytokines from cultured endothelial cellsBlood. 116: 2183-91. 7. Wakui, S. et al. (1999) Expression of vascular endothelial growth factor in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis.Vet Pathol. 36: 111-6. 8. Jaschke, B. et al. (2005) Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform.Cardiovasc Res. 68: 483-92. 9. Larochelle, N. et al. (2008) Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses.Hum Gene Ther. 19: 133-42. 10. Mirsky, R. et al. (2011) Treatment of pulmonary arterial hypertension with circulating angiogenic cells.Am J Physiol Lung Cell Mol Physiol. 301: L12-9.
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