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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human SNAP-25 Antibody, clone SP12    

Anti-Human SNAP-25 Antibody, clone SP12

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human SNAP-25 Antibody, clone SP12  ABD10095
    Human Cerebellar Granular Neurons stained with Mouse anti Human SNAP-25
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P60880
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names SP12
Calculated MW 23315 Da
Additional Information
Other Species Ha,Pig,Rat,Gerbil
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Crude human synaptic immunoprecipitate.
Shelf Life 18 months from date of despatch.
Gene ID 6616
Other Names Synaptosomal-associated protein 25, SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein, SNAP25, SNAP
Target/Specificity Mouse anti-Human SNAP-25 antibody, clone SP12 recognizes the human pre-synaptic protein, SNAP-25, also known as Synaptosomal-associated protein 25, Super protein (SUP) or Synaptosomal-associated 25 kDa protein. SNAP-25 is a 206 amino acid  presynaptic protein of ~25kDa containing two t-SNARE coiled-coil homology domains. Mouse anti-human SNAP-25 antibody, clone SP12 will recognize SNAP-25 fusion protein from COS cells, but not the fusion protein from bacterial systems.Mouse anti-Human SNAP-25 antibody, clone SP12  has been used to study the distribution of synaptic changes in the hippocampus of patients with medically refractory temporal lobe epilepsy. (Honeret al.1994).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human SNAP-25 Antibody, clone SP12 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Honer, al. (1994) Hippocampal synaptic pathology in patients with temporal lobe epilepsy.
Acta Neuropathol. 87: 202-210. 2. Honer, W.G et al. (1992) Regional synaptic pathology in Alzheimer's disease.
Neurobiol. Aging. 13: 375-382. 3. Honer, W.G. et al. (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex.
Brain Res. 609: 9-20. 4. Honer, W.G. et al. (1992) Characterization of a synaptic antigen of interest in neuropsychiatric illness.
Biol. Psychiatry 31: 147-158. 5. Honer, al. (1989) Monoclonal antibodies to study the brain in schizophrenia.
Brain Res. 500: 379-383. 6. Masliah, E. et al. (1994) Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus.
Acta Neuropathol. 87: 135-142. 7. Simpson, I.A. et al. (1994) Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease.
Ann Neurol. 35: 546-551. 8. Wakabayashi, K. et al. (1994) Synapse alterations in the hippocampalentorhinal formation in Alzheimer's disease with and without Lewy body disease.
Brain Res. 667: 24-32. 9. Dickson, D.W. et al. (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans.
Acta Neuropathologica 88: 212-221. 10. Dickson, D.W. et al. (1995) Correlations of synaptic and pathological markers with cognition of the elderly.
Neurobiol. Aging 16: 285-98. 11. Bragina, L. et al. (2006) GLT-1 down-regulation induced by clozapine in rat frontal cortex is associated with synaptophysin up-regulation.
J Neurochem. 99: 134-41. 12. Steel, G.J. et al. (1997) Evidence for interaction of the fusion protein alpha-SNAP with membrane lipid.
Biochem J. 325 : 511-8. 13. Reed, G.L. et al. (1999) Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.
Blood. 93: 2617-26. 14. Vannucchi, M.G. et al. (2000) Synapse formation during neuron differentiation: an in situ study of the myenteric plexus during murine embryonic life.
J Comp Neurol. 425: 369-81. 15. Lemons, P.P. et al. (1997) Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.
Blood. 90: 1490-500. 16. Mukaetova-Ladinska, E.B. et al. (2000) Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease.
Am J Pathol. 157: 623-36. 17. Sawada, K. et al. (2002) Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness.
Mol Psychiatry. 7: 484-92. 19. Chen, H.Y. et al. (2009) Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats.
J Pineal Res. 47: 260-70. 20. Ishimaru, H. et al. (2001) Changes in presynaptic proteins, SNAP-25 and synaptophysin, in the hippocampal CA1 area in ischemic gerbils.
Brain Res. 903: 94-101.

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Cat# ABD10095
(40 western blots)
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