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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse MAdCAM-1 Antibody, clone MECA-367    

Anti-Mouse MAdCAM-1 Antibody, clone MECA-367

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q61826
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names MECA-367
Calculated MW 43652 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Balb/c mouse endothelial cells
Shelf Life 18 months from date of despatch.
Gene ID 17123
Other Names Mucosal addressin cell adhesion molecule 1, MAdCAM-1, mMAdCAM-1, Madcam1
Target/Specificity Rat anti-Mouse MAdCAM-1 antibody, clone MECA-367 recognizes murine mucosal vascular addressin, MAdCAM-1. The antibody binds to the N-terminal Ig domain involved in a4b7 integrin binding.MAdCAM-1 is an Ig family member preferentially expressed in mucosal lymphoid tissues and lamina propria.Rat anti-Mouse MAdCAM-1 antibody, clone MECA-367 blocks MadCAM-1 dependent binding in vitro.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse MAdCAM-1 Antibody, clone MECA-367 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Briskin, M.J. et al. (1993) MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1.
Nature. 363 (6428): 461-4. 2. Streeter, P.R. et al. (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing.
Nature. 331 (6151): 41-6. 3. Berg, E.L. et al. (1993) L-selectin-mediated lymphocyte rolling on MAdCAM-1.
Nature. 366 (6456): 695-8. 4. Henderson, R.B. et al. (2010) A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
J Exp Med. 207: 837-53. 5. Cadman, E.T. et al. (2008) Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity.
Infect Immun. 76: 3924-31. 6. Cupedo, T. et al. (2004) Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes.
J Immunol. 173: 2968-75. 7. Whiting, C.V. et al. (2003) Abnormal mucosal extracellular matrix deposition is associated with increased TGF-beta receptor-expressing mesenchymal cells in a mouse model of colitis.
J Histochem Cytochem. 51: 1177-89. 8. McCulloch, L. et al. (2013) Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function.
Immunology. 138 (3): 246-57. 9. Frederico, B. et al. (2014) A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread.
Cell Host Microbe. 15 (4): 457-70. 10. Katakai, T. et al. (2008) Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.
J Immunol. 181 (9): 6189-200. 11. Goto, A. et al. (2006) Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis.
Inflamm Bowel Dis. 12 (8): 758-65. 12. Ito H et al. (2002) Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease.
J Gastroenterol. 37 Suppl 14: 56-61. 13. Engwerda, C.R. et al. (2002) A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovaniinfection.
Am J Pathol. 161 (2): 429-37. 14. Williams, A.M. et al. (2006) Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse.
Immunology. 119 (4): 470-8. 15. Zhi K et al. (2014) α4β7 Integrin (LPAM-1) is upregulated at atherosclerotic lesions and is involved in atherosclerosis progression.
Cell Physiol Biochem. 33 (6): 1876-87. 16. Svensson, M. et al. (2004) Stromal cells direct local differentiation of regulatory dendritic cells.
Immunity. 21 (6): 805-16.

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