|Application ||WB, IHC-F, IF, IP|
|Calculated MW||43652 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Balb/c mouse endothelial cells|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mucosal addressin cell adhesion molecule 1, MAdCAM-1, mMAdCAM-1, Madcam1|
|Target/Specificity||Rat anti-Mouse MAdCAM-1 antibody, clone MECA-367 recognizes murine mucosal vascular addressin, MAdCAM-1. The antibody binds to the N-terminal Ig domain involved in a4b7 integrin binding.MAdCAM-1 is an Ig family member preferentially expressed in mucosal lymphoid tissues and lamina propria.Rat anti-Mouse MAdCAM-1 antibody, clone MECA-367 blocks MadCAM-1 dependent binding in vitro.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse MAdCAM-1 Antibody, clone MECA-367 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Briskin, M.J. et al. (1993) MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1.Nature. 363 (6428): 461-4. 2. Streeter, P.R. et al. (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing.Nature. 331 (6151): 41-6. 3. Berg, E.L. et al. (1993) L-selectin-mediated lymphocyte rolling on MAdCAM-1.Nature. 366 (6456): 695-8. 4. Henderson, R.B. et al. (2010) A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.J Exp Med. 207: 837-53. 5. Cadman, E.T. et al. (2008) Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity.Infect Immun. 76: 3924-31. 6. Cupedo, T. et al. (2004) Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes.J Immunol. 173: 2968-75. 7. Whiting, C.V. et al. (2003) Abnormal mucosal extracellular matrix deposition is associated with increased TGF-beta receptor-expressing mesenchymal cells in a mouse model of colitis.J Histochem Cytochem. 51: 1177-89. 8. McCulloch, L. et al. (2013) Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function.Immunology. 138 (3): 246-57. 9. Frederico, B. et al. (2014) A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread.Cell Host Microbe. 15 (4): 457-70. 10. Katakai, T. et al. (2008) Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.J Immunol. 181 (9): 6189-200. 11. Goto, A. et al. (2006) Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis.Inflamm Bowel Dis. 12 (8): 758-65. 12. Ito H et al. (2002) Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease.J Gastroenterol. 37 Suppl 14: 56-61. 13. Engwerda, C.R. et al. (2002) A role for tumor necrosis factor-alpha in remodeling the splenic marginal zone during Leishmania donovaniinfection.Am J Pathol. 161 (2): 429-37. 14. Williams, A.M. et al. (2006) Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse.Immunology. 119 (4): 470-8. 15. Zhi K et al. (2014) α4β7 Integrin (LPAM-1) is upregulated at atherosclerotic lesions and is involved in atherosclerosis progression.Cell Physiol Biochem. 33 (6): 1876-87. 16. Svensson, M. et al. (2004) Stromal cells direct local differentiation of regulatory dendritic cells.Immunity. 21 (6): 805-16.
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