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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human CD70 Antibody, clone Bu69    

Anti-Human CD70 Antibody, clone Bu69

Mouse Anti-Human Monoclonal Antibody

     
  • IF - Anti-Human CD70 Antibody, clone Bu69  ABD10107
    Immunofluorescence staining of a human tonsil cryosection with Mouse anti Human CD70 antibody, clone Bu69 , red in A and Mouse anti Human CD21 antibody, clone LB21 , green in B. C is the merged image with nuclei counterstained blue using DAPI. High power
  • IHC - Anti-Human CD70 Antibody, clone Bu69  ABD10107
    Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD70 antibody, clone Bu69 followed by the Histar setection system . Low power
  • IHC - Anti-Human CD70 Antibody, clone Bu69  ABD10107
    Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD70 antibody, clone Bu69 followed by the Histar setection system . Medium power
  • IF - Anti-Human CD70 Antibody, clone Bu69  ABD10107
    Immunofluorescence staining of a human tonsil cryosection with Mouse anti Human CD70 antibody, clone Bu69 , red in A and Mouse anti Human CD21 antibody, clone LB21 , green in B. C is the merged image with nuclei counterstained blue using DAPI. Low power
  • IHC - Anti-Human CD70 Antibody, clone Bu69  ABD10107
    Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD70 antibody, clone Bu69 followed by the Histar setection system . High power
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, FC
Primary Accession P32970
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names Bu69
Calculated MW 21118 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Shelf Life 18 months from date of despatch.
Gene ID 970
Other Names CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7
Target/Specificity Mouse anti-Human CD70 antibody, clone Bu69 recognises human CD70, also known as CD27 ligand (CD27-L) or Tumor necrosis factor ligand superfamily member 7. CD70 is a 193 amino acid ~29kDa single pass type II transmembrane glycoprotein belonging to the tumour necrosis factor (TNF) family (UniProt: P32970).CD70 is expressed on a small number of activated T-cells and the majority of activated B-cells (Bowmanet al.1994). Interaction of CD70 with its receptor, CD27, is thought to play an important role in lymphocyte activation, proliferation, survival and differentiation (Hintzenet al.1994).Mouse anti-Human CD70 antibody, clone Bu69 has been used for the inhibition of neural stem cell induced apoptosis of allogeneic T cells in vitro(Leeet al.2013).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD70 Antibody, clone Bu69 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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References

1. Garland Publishing. (1997) Leucocyte typing VI. White cell differentiation antigens.
p522 – 524 2. Zambello, R. et al. (2000) Analysis of TNF-receptor and ligand superfamily molecules in patients with lymphoproliferative disease of granular lymphocytes.
Blood. 96: 647-54 3. Lee, E.M. et al. (2013) CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.
Stem Cell Res Ther. 4: 56.

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Cat# ABD10107
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