|Calculated MW||137910 Da|
|Purification||Purified IgG prepared by ion exchange chromatography from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Receptor tyrosine-protein kinase erbB-2, 220.127.116.11, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL|
|Target/Specificity||This antibody recognises epitope C of human HER2/neu, otherwise known as CD340 and c-ErbB-2, a proto-oncogene expressed at the cell surface of a range of tumour cells, which is often associated with poor prognosis, and an increased risk of metastasis.HER2/neu is used in conjunction with antibodies recognising both Estrogen and Progesterone receptors, for the classification of breast cancer tumours, and to determine patient prognosis and course of treatment. Excessive HER2/neu is present in around 20% to 25% of invasive breast cancers, referred to as HER2-positive cancer, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), might be beneficial.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human HER2/neu Antibody, clone ICR52 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Styles, J. M. et al. (1990) Rat monoclonal antibodies to the external domain of the product of the c-erbB-2 proto-oncogene.Int. J. Cancer 45: 320-324. 2. Dean, C. J. et al. (1993) Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer.Cell. Biophys. 22 (1-3): 111-127.
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