|Application ||WB, IHC-P, IHC-F|
|Calculated MW||106159 Da|
|Immunogen||Recombinant human retinoblastoma gene protein|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1|
|Target/Specificity||Mouse anti-Human Retinoblastoma Gene Protein antibody, clone IF8 recognizes the human retinoblastoma (Rb) gene product. Rb is a tumor suppressor protein which may act upon the transcription factor ATF-2.Rb gene mutation may be associated with tumor development.|
|Preservative & Stabilisers||15mM Sodium Azide|
|Storage||Storage at 4℃ or at -20℃.|
|Precautions||Anti-Human Retinoblastoma Gene Protein Antibody, clone IF8 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Bártek, J. et al. (1992) Cellular localization and T antigen binding of the retinoblastoma protein.Oncogene. 7: 101-8. 2. Markiewicz, E. et al. (2002) Lamin A/C Binding Protein LAP2a Is Required for Nuclear Anchorage of Retinoblastoma ProteinMol Biol Cell. 13: 4401-13. 3. Paggi, M.G. et al. (1994) Defective human retinoblastoma protein identified by lack of interaction with the E1A oncoprotein.Cancer Res. 54: 1098-104. 4. Reynisdóttir, I. et al. (1999) The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.J Virol. 73: 3004-13. 5. Zamanian, M. and La Thangue, N.B. (1993) Transcriptional repression by the Rb-related protein p107.Mol Biol Cell. 4: 389-96. 6. Fåhraeus, R. et al. (1996) Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A.Curr Biol. 6: 84-91. 7. Ahuja, H.G. et al. (1991) Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia.Blood. 78: 3259-68.
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