|Application ||WB, IHC-P|
|Calculated MW||82286 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Bacterially expressed human Mcm5.|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA replication licensing factor MCM5, 188.8.131.52, CDC46 homolog, P1-CDC46, MCM5, CDC46|
|Target/Specificity||Mouse anti-Human Mcm5 antibody, clone CRCT5.1 recognizes human Mcm-5 (minichromosome maintenance protein 5), also known as DNA replication licensing factor MCM5 or P1-CDC46. Mcm5 is a nuclear protein of ~95kDa with an important role in the control of DNA replication (Snyderet al.2005).It has been reported that immunocytochemical assessment of Mcm5 expression may be of value in improving the accuracy of cervical smear testing for the detection of malignancy (Murphyet al.2004).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Mcm5 Antibody, clone CRCT5.1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Dart, D.A. et al. (2004) Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. J Biol Chem. 279: 16433-40. 2. Adams, K.E. et al. (2006) Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.Oncogene. 25: 3894–904. 3. Gakiopoulou, H. et al. (2007) Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications.British Journal of Cancer 97: 1124–34. 4. Guida, T. et al. (2005) Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma.J Clin Endocrinol Metab. 90: 4703-9. 5. Polo, S.E. et al. (2010) Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours.Histopathology. 57: 716-24.1. Williams, G.H. et al. (1998) Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc. Natl. Acad. Sci. USA. 14932-14937.
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