|Application ||FC, E, IP|
|Calculated MW||129295 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Purified human b1 integrin preparation from HT1080 fibrosarcoma cell extract.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Target/Specificity||Mouse anti-Human CD49b antibody, clone 31H4 recognizes human CD49b also known as integrin alpha-2, VLA-2 subunit alpha or collogen receptor. CD49b is a 1181 amino acid ¦130 kDa single pass type-1 transmembrane glycoprotein which forms a heterodimer with integrin beta-1.Mouse anti-Human CD49b antibody, clone 31H4 has been identified as being capable of immunoprecipitating the integrin a2 subunit from human cell-lines surface labelled with 125I. It has been confirmed specific to a2 by relative expression of antigen on various cell lines by flow cytometry, and recognition of affinity purified a2b1 in dot blots.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD49b Antibody, clone 31H4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tanaka, T. et al. (2009) Remodeling of the human endometrial epithelium is regulated by laminin and type IV collagen.Int J Mol Med. 23: 173-80. 2. Tanaka, T. et al. (2005) Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells.Oncol Rep. 14: 941-8. 3. Tanaka, T. et al. (2010) Establishment and characterization of novel human uterine leiomyosarcoma cell linesInt J Oncol. 37: 125-31. 4. Tanaka, T. et al. (2012) Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells.Int J Oncol. 41: 1837-44. 5. Tanaka, T. et al. (2008) Autocrine/paracrine regulation of human endometrial stromal remodeling by laminin and type IV collagen.Int J Mol Med. 22: 581-7. 6. Tanaka, T. et al. (2006) Optimal combination chemotherapy and chemoradiotherapy with etoposide for advanced cervical squamous cancer cells in vitro.Oncol Rep. 15: 939-47. 7. Tanaka, T. et al. (2012) Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells.Oncol Rep. 28: 330-6. 8. Tanaka, T. et al. (2008) Experimental characterization of recurrent ovarian immature teratoma cells after optimal surgery.Oncol Rep. 20: 13-23.
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