|Calculated MW||20808 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||CHO cells transfected with B6 allele of CD94|
|Shelf Life||18 months from date of despatch.|
|Other Names||Natural killer cells antigen CD94, Killer cell lectin-like receptor subfamily D member 1, CD94, Klrd1, Cd94|
|Target/Specificity||Rat anti-Mouse CD94 antibody, clone 18d3 recognizes murine CD94, a 70kDa cell surface glycoprotein expressed primarily by mouse natural killer (NK) cells. The murine CD94 molecule forms heterodimers with NKG2A, C or E subunits to form the CD94/NKG2 receptor.In mice the CD94/NKG2 receptor recognizes Qa-1b, a non-classical MHC class 1 molecule. CD94/NKG2 receptors may play an important role in self-tolerance of NK cells during fetal and neonatal life. N.B. Recent reports suggest that DBA/2J mice do not express cell surface CD94/NKG2A receptors (Vanceet al.2002).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD94 Antibody, clone 18d3 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Vance, R.E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire function.Proc. Natl. Acad. Sci. USA. 99:868-873. 2. Vance, R.E. et al. (1999) Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors CD94/NKG2C and CD94/NKG2E on Mouse Natural Killer Cells.J. Exp. Med. 190:1801-1812. 3. Chattopadhyay, S.et al. (2008) Implication for the CD94/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells.Int. Immunol. 20: 509-516. 4. Kawamura. H. et al. (2005) Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.Eur. J. Immunol. 35: 2358-66.
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