|Application ||WB, FC, IP|
|Clone Names||HM alpha 5|
|Calculated MW||115043 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Purified mouse VLA-5 protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, Itga5|
|Target/Specificity||Hamster anti-Mouse CD49e antibody, clone HM alpha 5 recognizes the mouse integrin alpha 5 subunit (CD49e). CD49e is a type I membrane protein that associates non-covalently with integrin beta 1 (CD29) to form the heterodimer CD49e/CD29 (VLA-5). VLA-5 is expressed on mast cells, splenic B cells, thymocytes, T-cells and monocytes. The VLA-5 heterodimer forms the fibronectin receptor, which plays an important role in cell adhesion and migration.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD49e Antibody, clone HM alpha 5 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Yasuda, M. et al. (1995) Expression and function of fibronectin binding integrins on rat mast cells.Int. Immunol. 7: 251 - 258. 2. Miyake, S. et al. (1994) Identification of collagen and laminin receptor integrins on murine T lymphocytes.Eur. J. Immunol. 24: 2000 - 2005. 3. Carpinteiro A et al. (2015) Regulation of hematogenous tumor metastasis by acid sphingomyelinase.EMBO Mol Med. pii: e201404571.
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