|Application ||WB, IHC-P, FC, E|
|Calculated MW||40155 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Recombinant soluble MAdCAM-1-fc fusion protein.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mucosal addressin cell adhesion molecule 1, MAdCAM-1, hMAdCAM-1, MADCAM1|
|Target/Specificity||Mouse anti-Human MAdCAM-1 antibody, clone 17F5 recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a ~60 kDa transmembrane protein that belongs to the immunoglobulin superfamily. MAdCAM-1 is strongly expressed on mucosal lymphoid tissue and high endothelial venules of Peyer's patches. Human MAdCAM-1 interacts with the beta 7 integrin LPAM-1 (alpha4beta7), CD62L, and VLA-4 (alpha4beta1) and is involved in lymphocyte trafficking, Clone 17F5 recognizes the mucin domain of MAdCAM-1. This antibody does not block the function of MAdCAM-1 (Leung, E. et al.2004).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human MAdCAM-1 Antibody, clone 17F5 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Leung, E. et al. (1996) Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts.Immunol Cell Biol. 74 (6): 490-6. 2. Leung, E. et al. (2004) Bioassay detects soluble MAdCAM-1 in body fluids.Immunol Cell Biol. 82 (4): 400-9. 3. AL-Mohammed Salem K.T. (2012) Adhesion Molecules and the Cellular Population of the Normal Camel (Camelus dromedaries) Mammary GlandsThe Open Veterinary Science Journal. 6 (1): 15-22. 4. Guerra-Pérez N et al. (2015) Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection.J Immunol. 194 (5): 2415-23.
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