|Application ||FC, IP|
|Calculated MW||50089 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Fusion protein containing the extracellular region of CD261 (DR4).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, CD261, TNFRSF10A, APO2, DR4, TRAILR1|
|Target/Specificity||Mouse anti-Human CD261 antibody, clone DR-4-02 recognizes human death receptor 4 (DR4), also known as CD261 or TRAIL- R1. DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines. DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD261 Antibody, clone DR-4-02 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cosgrove, C. et al. (2013) Early and nonreversible decrease of CD161++/MAIT cells in HIV infection.Blood. 121: 951-61. 2. Crescenzi, E. et al. (2011) NF-?B-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells.Oncogene. 30: 2707-17. 3. Zhang, Y. and Zhang, B. (2008) TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.Mol Cancer Res. 6: 1861-71.
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