|Application ||FC, IP|
|Calculated MW||50089 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Fusion protein containing the extracellular region of CD261 (DR4).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, CD261, TNFRSF10A, APO2, DR4, TRAILR1|
|Target/Specificity||Mouse anti-Human CD261 antibody, clone DR-4-02 recognizes human death receptor 4 (DR4), also known as CD261 or TRAIL- R1. DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines. DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD261 Antibody, clone DR-4-02 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cosgrove, C. et al. (2013) Early and nonreversible decrease of CD161++/MAIT cells in HIV infection.Blood. 121: 951-61. 2. Crescenzi, E. et al. (2011) NF-?B-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells.Oncogene. 30: 2707-17. 3. Zhang, Y. and Zhang, B. (2008) TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.Mol Cancer Res. 6: 1861-71.
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