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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse ER-MP58 Antibody, clone ER-MP58    

Anti-Mouse ER-MP58 Antibody, clone ER-MP58

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names ER-MP58
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Balb/c macrophage precursor cell hybrids
Shelf Life 12 months from date of reconstitution.
Target/Specificity Rat anti-Mouse ER-MP58 antibody, clone ER-MP58 recognizes the murine antigen ER-MP58, which is expressed by all bone marrow-derived M-CSF- and GM-CSF-responsive myeloid blood cell precursors.The expression of ER-MP58 remains at a high level throughout the precursor/monocyte stage and is down-regulated upon maturation into mature macrophages. The ER-MP58 antigen is used to distinguish between early myeloid-committed cells and other haematopoietic progenitors cells in the BM. The antigen has been used as a marker of murine macrophage development in the BM.ER-MP58 is suitable for the identification of myeloid haemopoietic islands in various organs, and for embryonal studies.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse ER-MP58 Antibody, clone ER-MP58 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Leenen, P.J. et al. (1990) Murine macrophage precursor characterization II.
Monoclonal antibodies against macrophage precursor antigens. Eur. J. Immunol. 20: 27–34. 2. Henkel, G.W. et al. (1999) Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1
Blood. 93: 2849–2858. 3. Nikolic, T. et al. (2003) Developmental stages of myeloid dendritic cells in mouse bone marrow.
Int. Immunol.15: 515-524. 4. Geutskens, S.B. et al. (2005) Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
J Leukoc Biol. 78: 845-52. 5. Sunderkötter, C. et al. (2004) Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.
J Immunol. 172: 4410-7. 6. Chan, J. et al., (1998) Macrophage lineage cells in inflammation: characterization by colony-stimulating factor-1 (CSF-1) receptor (c-Fms), ER-MP58, and ER-MP20 (Ly-6C) expression.
Blood. 1998 Aug 92: 1423-31. 7. Sunderkötter, C. et al. (2004) Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.
J Immunol. 172: 4410-7. 8. Wynn, A.A. et al. (2001) Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation.
Am J Pathol. 158: 131-45. 9. Rössner, S. et al. (2005) Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro.
Eur J Immunol. 35: 3533-44. 10. Goossens, P. et al. (2011) Myeloid I?Ba deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques.
PLoS One. 6: e22327. 11. Iwasaki, Y. et al. (2011) In situ proliferation and differentiation of macrophages in dental pulp.
Cell Tissue Res. 346: 99-109. 12. Mossink, M.H. et al. (2003) Unimpaired dendritic cell functions in MVP/LRP knockout mice.
Immunology. 110: 58-65. 13. Oliveira, M.A. et al. (2003) Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation.
J Leukoc Biol. 74: 857-67. 14. de Bruijn, M.F. et al. (1996) High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage.
Eur J Immunol. 26: 2850-8. 15. Oomen, S.P. et al. (2002) Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells.
Exp Hematol. 30: 116-25. 16. Welzen-Coppens, J.M. et al. (2012) Abnormalities of dendritic cell precursors in the pancreas of the NOD mouse model of diabetes.
Eur J Immunol. 42: 186-94. 17. Hoeksema, M.A. et al. (2014) Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
EMBO Mol Med. pii: e201404170.

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