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Anti-FOXP1 Antibody, clone JC12

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H334
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names JC12
Calculated MW 75317 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Shelf Life 18 months from date of despatch.
Gene ID 27086
Other Names Forkhead box protein P1, Mac-1-regulated forkhead, MFH, FOXP1
Target/Specificity Mouse anti-FOXP1 antibody, clone JC12 recognizes human FOXP1, an 85kD member of the winged helix/forkhead transcription factor family. The FOXP1 transcription factor is widely expressed in human tissues and is predominantly localised to the nucleus. However, the level of expression does vary between cells and between different tissues. The expression of FOXP1 is reported to be abnormal in a range of solid tumours. Studies suggest that FOXP1 functions as a transcriptional repressor.The antibody produced by clone JC12 does not recognize closely related molecules FOXP2, FOXP3 or FOXP4.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-FOXP1 Antibody, clone JC12 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Banham, A.H. et al. (2005) Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.
Clin. Cancer Res.11:1065 – 1072. 2. Banham, A.H. et al. (2001) The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
Cancer Res. 61:8820 – 8829. 3. Yamada, S. et al. (2012) Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specified.
Hum Pathol. 43 (8): 1322-7. 4. Yu, B. et al. (2011) FOXP1 expression and its clinicopathologic significance in nodal and extranodal diffuse large B-cell lymphoma.
Ann Hematol. 90 (6): 701-8. 5. Hu, C.R. et al. (2013) Both FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma: a retrospective study in China.
Acta Histochem. 115 (2): 137-43. 6. Hoefnagel, J.J. et al. (2006) Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma.
Mod Pathol. 19 (9): 1270-6. 7. Marafioti, T. et al. (2008) Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Blood. 111 (7): 3778-92.

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Cat# ABD10172
(40 western blots)
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