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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD206 Antibody, clone 7-450    

Anti-Human CD206 Antibody, clone 7-450

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD206 Antibody, clone 7-450  ABD10175
    Staining of frozen Human Tonsil stained with Mouse anti Human CD206
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22897
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 7-450
Calculated MW 166012 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Monocyte-derived dendritic cells.
Shelf Life 18 months from date of despatch.
Gene ID 4360
Other Names Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Macrophage mannose receptor 1-like protein 1, CD206, MRC1, CLEC13D, CLEC13DL, MRC1L1
Target/Specificity Mouse anti-Human CD206 antibody, clone 7-450 recognizes human CD206, otherwise known as macrophage mannose receptor (MMR), a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens.CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD206 Antibody, clone 7-450 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Stahl, P.D. & Ezekowitz, R.A. (1998) The mannose receptor is a pattern recognition receptor involved in host defense.
Curr Opin Immunol. 10 (1): 50-5.1. Gordon, S. (1995) The macrophage.
Bioessays. 17 (11): 977-86.

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Cat# ABD10175
(40 western blots)
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